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HomoloGene:180. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   JAG1,  H.sapiens
jagged 1
    NP_000205.1
1218 aa
   JAG1,  P.troglodytes
jagged 1
    XP_001169666.1
1218 aa
   JAG1,  M.mulatta
jagged 1
    XP_001116216.2
1181 aa
   JAG1,  C.lupus
jagged 1
    XP_005634840.1
1218 aa
   JAG1,  B.taurus
jagged 1
    NP_001178107.1
1218 aa
   Jag1,  M.musculus
jagged 1
    NP_038850.1
1218 aa
   Jag1,  R.norvegicus
jagged 1
    NP_062020.1
1219 aa
   JAG1,  G.gallus
jagged 1
    XP_415035.4
1216 aa
   jag1,  X.tropicalis
jagged 1
    XP_002931784.1
1218 aa
   jag1b,  D.rerio
jagged 1b
    NP_571938.1
1213 aa
   Ser,  D.melanogaster
Serrate
    NP_524527.3
1407 aa
   AgaP_AGAP004154,  A.gambiae
AgaP_AGAP004154
    XP_313038.5
1370 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Originally recovered alleles were recessive lethal with a dominant incised-wing phenotype; SerBd-1 was very weak and highly variable when first recovered, but gained expressivity with selection; subsequently isolated alleles were stronger. Wings reduced by marginal excision both anteriorly and posteriorly. Phenotype of SerBd-1/SerBd-1/+ extreme (Peter Lewis). Expression and interaction studied by Goldschmidt and Gardner (1942). Expression of SerBd-1, SerBd-3 and Ser1 suppressed by H (Bridges, 1938) and Ax alleles (Bang). (See FlyBase for complete description.)

H.sapiens
Alagille syndrome.
Tetralogy of Fallot.
Deafness, congenital heart defects, and posterior embryotoxon.



Publications
Articles associated with genes and sequences of this homology group.

Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice.
Sargin D, et al. Neurobiol Learn Mem 103, 39-49 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
VWC_out (smart00215)
  von Willebrand factor (vWF) type C domain.
MNNL (pfam07657)
  N terminus of Notch ligand.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
MNNL (pfam07657)
  N terminus of Notch ligand.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
DSL (cl19567)
  Delta serrate ligand.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Jag1 includes H.sapiens JAG1 and R.norvegicus Jag1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

 

 

 

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