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HomoloGene:4742. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MCAM,  H.sapiens
melanoma cell adhesion molecule
646 aa
   MCAM,  P.troglodytes
melanoma cell adhesion molecule
646 aa
   MCAM,  C.lupus
melanoma cell adhesion molecule
630 aa
   Mcam,  M.musculus
melanoma cell adhesion molecule
648 aa
   Mcam,  R.norvegicus
melanoma cell adhesion molecule
648 aa
   MCAM,  G.gallus
melanoma cell adhesion molecule
626 aa
   mcam,  X.tropicalis
melanoma cell adhesion molecule
629 aa
   LOC566921,  D.rerio
cell surface glycoprotein MUC18-like
633 aa
   mcamb,  D.rerio
melanoma cell adhesion molecule b
617 aa
   LOC101884730,  D.rerio
cell surface glycoprotein MUC18-like
629 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Perivascular support of human hematopoietic stem/progenitor cells.
Corselli M, et al. Blood 121, 2891-901 (2013).
Soluble CD146 in cerebrospinal fluid of active multiple sclerosis.
Duan H, et al. Neuroscience 235, 16-26 (2013).
CD146, a multi-functional molecule beyond adhesion.
Wang Z & Yan X. Cancer Lett 330, 150-62 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
I-set (pfam07679)
  Immunoglobulin I-set domain.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IG_like (smart00410)
  Immunoglobulin like.
V-set (pfam07686)
  Immunoglobulin V-set domain.
C2-set_2 (pfam08205)
  CD80-like C2-set immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
DUF4448 (pfam14610)
  Protein of unknown function (DUF4448).
Ig (cl11960)
  Immunoglobulin domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mcam includes H.sapiens MCAM and R.norvegicus Mcam.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)




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