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HomoloGene:57022. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OPA3,  H.sapiens
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
    NP_001017989.2
180 aa
   OPA3,  C.lupus
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
    XP_855096.1
192 aa
   OPA3,  B.taurus
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
    NP_001232863.1
186 aa
   Opa3,  M.musculus
optic atrophy 3
    NP_997408.2
179 aa
   opa3,  X.tropicalis
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
    XP_002932648.1
151 aa
   opa3,  D.rerio
optic atrophy 3
    NP_001073635.1
157 aa
   CG13601,  D.melanogaster
CG13601
    NP_001262890.1
277 aa
   AgaP_AGAP001401,  A.gambiae
AgaP_AGAP001401
    XP_321733.4
213 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Optic atrophy and cataract.
3-methylglutaconic aciduria, type III.



Publications
Articles associated with genes and sequences of this homology group.

OPA3-Related 3-Methylglutaconic Aciduria
Gunay-Aygun M, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OPA3 (pfam07047)
  Optic atrophy 3 protein (OPA3).
OPA3 (pfam07047)
  Optic atrophy 3 protein (OPA3).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Opa3 includes H.sapiens OPA3 and R.norvegicus Opa3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 11 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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