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HomoloGene:23264. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ALS2,  H.sapiens
amyotrophic lateral sclerosis 2 (juvenile)
    NP_065970.2
1657 aa
   ALS2,  P.troglodytes
amyotrophic lateral sclerosis 2 (juvenile)
    NP_001073389.1
1657 aa
   ALS2,  M.mulatta
amyotrophic lateral sclerosis 2 (juvenile)
    XP_001091562.2
1651 aa
   ALS2,  C.lupus
amyotrophic lateral sclerosis 2 (juvenile)
    XP_003640234.1
1656 aa
   ALS2,  B.taurus
amyotrophic lateral sclerosis 2 (juvenile)
    XP_005202742.1
1656 aa
   Als2,  M.musculus
amyotrophic lateral sclerosis 2 (juvenile)
    NP_001153420.2
1651 aa
   Als2,  R.norvegicus
amyotrophic lateral sclerosis 2 (juvenile)
    NP_001013431.1
1651 aa
   ALS2,  G.gallus
amyotrophic lateral sclerosis 2 (juvenile)
    XP_421940.2
1649 aa
   als2,  X.tropicalis
amyotrophic lateral sclerosis 2 (juvenile)
    XP_004917813.1
1644 aa
   als2b,  D.rerio
amyotrophic lateral sclerosis 2b (juvenile)
    XP_002662342.2
1681 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyotrophic lateral sclerosis, juvenile.
Primary lateral sclerosis, juvenile.
Spastic paralysis, infantile onset ascending.



Publications
Articles associated with genes and sequences of this homology group.

A novel compound heterozygous ALS2 mutation in two Italian siblings with juvenile amyotrophic lateral sclerosis.
Luigetti M, et al. Amyotroph Lateral Scler Frontotemporal Degener 14, 470-2 (2013).
ALS2-Related Disorders
Bertini ES, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RCC1 (pfam00415)
  Regulator of chromosome condensation (RCC1) repeat.
MORN (pfam02493)
  MORN repeat.
RCC1_2 (pfam13540)
  Regulator of chromosome condensation (RCC1) repeat.
VPS9 (pfam02204)
  Vacuolar sorting protein 9 (VPS9) domain.
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
RCC1 (pfam00415)
  Regulator of chromosome condensation (RCC1) repeat.
RCC1_2 (pfam13540)
  Regulator of chromosome condensation (RCC1) repeat.
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
MORN (cl14787)
  MORN repeat.
PH-like (cl17171)
  Pleckstrin homology-like domain.
VPS9 (cl19569)
  Vacuolar sorting protein 9 (VPS9) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Als2 includes H.sapiens ALS2 and R.norvegicus Als2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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