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HomoloGene:37263. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TOR1A,  H.sapiens
torsin family 1, member A (torsin A)
    NP_000104.1
332 aa
   TOR1A,  P.troglodytes
torsin family 1, member A (torsin A)
    XP_001164380.2
364 aa
   TOR1A,  C.lupus
torsin family 1, member A (torsin A)
    XP_548417.3
332 aa
   TOR1A,  B.taurus
torsin family 1, member A (torsin A)
    NP_001092528.1
333 aa
   Tor1a,  M.musculus
torsin family 1, member A (torsin A)
    NP_659133.1
333 aa
   Tor1a,  R.norvegicus
torsin family 1, member A
    NP_695215.2
333 aa
   TOR1A,  G.gallus
torsin family 1, member A (torsin A)
    NP_001025858.1
344 aa
   tor1b,  X.tropicalis
torsin family 1, member B (torsin B)
    NP_001016237.1
327 aa
   Torsin,  D.melanogaster
Torsin
    NP_572178.1
340 aa
   AgaP_AGAP009547,  A.gambiae
AgaP_AGAP009547
    XP_310142.4
347 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dystonia-1, torsion.
Dystonia, early-onset atypical, with myoclonic features.
Dystonia-1, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

Pre-synaptic release deficits in a DYT1 dystonia mouse model.
Yokoi F, et al. PLoS One 8, e72491 (2013).
Is TOR1A a risk factor in adult-onset primary torsion dystonia?
Groen JL, et al. Mov Disord 28, 827-31 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AAA (smart00382)
  ATPases associated with a variety of cellular activities.
clpA (COG0542)
  ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tor1a includes H.sapiens TOR1A and R.norvegicus Tor1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Amphibia - amphibians (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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