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HomoloGene:20547. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MMP12,  H.sapiens
matrix metallopeptidase 12 (macrophage elastase)
    NP_002417.2
470 aa
   MMP12,  P.troglodytes
matrix metallopeptidase 12 (macrophage elastase)
    XP_508724.2
470 aa
   MMP12,  M.mulatta
matrix metallopeptidase 12 (macrophage elastase)
    XP_001098589.1
470 aa
   MMP12,  C.lupus
matrix metallopeptidase 12 (macrophage elastase)
    XP_854594.2
470 aa
   MMP12,  B.taurus
matrix metallopeptidase 12 (macrophage elastase)
    NP_001193569.1
471 aa
   Mmp12,  M.musculus
matrix metallopeptidase 12
    NP_032631.3
473 aa
   Mmp12,  R.norvegicus
matrix metallopeptidase 12
    NP_446415.2
477 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Expression of matrix metalloproteinase-12 in aortic dissection.
Song Y, et al. BMC Cardiovasc Disord 13, 34 (2013).
Macrophage elastase (MMP-12) in expanding murine adipose tissue.
Bauters D, et al. Biochim Biophys Acta 1830, 2954-9 (2013).
Strain variation in response to lung ischemia: role of MMP-12.
Tankersley CG, et al. Respir Res 13, 93 (2012).
Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production.
Nelson MP, et al. Am J Physiol Lung Cell Mol Physiol 303, L469-75 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
HX (cd00094)
  Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mmp12 includes H.sapiens MMP12 and R.norvegicus Mmp12.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)

 

 

 

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