Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:37279. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MTM1,  H.sapiens
myotubularin 1
    NP_000243.1
603 aa
   MTM1,  P.troglodytes
myotubularin 1
    XP_003317805.1
595 aa
   MTM1,  M.mulatta
myotubularin 1
    XP_002806476.1
603 aa
   MTM1,  C.lupus
myotubularin 1
    XP_005641991.1
603 aa
   MTM1,  B.taurus
myotubularin 1
    NP_001193354.1
603 aa
   Mtm1,  M.musculus
X-linked myotubular myopathy gene 1
    NP_001157662.1
603 aa
   Mtm1,  R.norvegicus
myotubularin 1
    NP_001013065.1
553 aa
   MTM1,  G.gallus
myotubularin 1
    XP_004940916.1
615 aa
   mtm1,  X.tropicalis
myotubularin 1
    NP_001015828.1
602 aa
   mtm1,  D.rerio
myotubularin 1
    NP_001032773.1
639 aa
   mtm-1,  C.elegans
mtm-1
    NP_491531.2
588 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myotubular myopathy, X-linked.



Publications
Articles associated with genes and sequences of this homology group.

Defective autophagy and mTORC1 signaling in myotubularin null mice.
Fetalvero KM, et al. Mol Cell Biol 33, 98-110 (2013).
Muscle function in a canine model of X-linked myotubular myopathy.
Grange RW, et al. Muscle Nerve 46, 588-91 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Y_phosphatase_m (pfam13849)
  Myotubularin Y_phosphatase-like.
Myotub-related (pfam06602)
  Myotubularin-related.
Myotub-related (pfam06602)
  Myotubularin-like phosphatase domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mtm1 includes H.sapiens MTM1 and R.norvegicus Mtm1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (11 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

Write to the Help Desk