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HomoloGene:38092. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RAD50,  H.sapiens
RAD50 homolog (S. cerevisiae)
    NP_005723.2
1312 aa
   RAD50,  P.troglodytes
RAD50 homolog (S. cerevisiae)
    XP_001163412.1
1312 aa
   RAD50,  M.mulatta
RAD50 homolog (S. cerevisiae)
    XP_001099384.2
1311 aa
   RAD50,  C.lupus
RAD50 homolog (S. cerevisiae)
    XP_531901.2
1312 aa
   RAD50,  B.taurus
RAD50 homolog (S. cerevisiae)
    NP_001193797.1
1312 aa
   Rad50,  M.musculus
RAD50 homolog (S. cerevisiae)
    NP_033038.2
1312 aa
   Rad50,  R.norvegicus
RAD50 homolog (S. cerevisiae)
    NP_071582.1
1312 aa
   RAD50,  G.gallus
RAD50 homolog (S. cerevisiae)
    XP_004945072.1
1313 aa
   rad50,  X.tropicalis
RAD50 homolog
    XP_004912891.1
1312 aa
   rad50,  D.rerio
RAD50 homolog (S. cerevisiae)
    XP_005167995.1
1312 aa
   rad50,  D.melanogaster
rad50
    NP_001246461.1
1318 aa
   AgaP_AGAP003676,  A.gambiae
AgaP_AGAP003676
    XP_313457.4
1308 aa
   MGG_11387,  M.oryzae
MGG_11387
    XP_003713570.1
1316 aa
   NCU00901,  N.crassa
NCU00901
    XP_963818.1
1314 aa
   RAD50,  A.thaliana
RAD50
    NP_565733.1
1316 aa
   Os02g0497500,  O.sativa
Os02g0497500
    NP_001046893.1
1316 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.
Williams A, et al. Proc Natl Acad Sci U S A 110, 6955-60 (2013).
Misregulation of Rad50 expression in melanoma cells.
Avaritt NL, et al. J Cutan Pathol 39, 680-4 (2012).
RAD50 gene mutations are not likely a risk factor for breast cancer in Poland.
Mosor M, et al. Breast Cancer Res Treat 123, 607-9 (2010).
Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.
Uhrhammer N, et al. Cancer Epidemiol Biomarkers Prev 18, 684-5 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Orbi_VP5 (pfam00901)
  Orbivirus outer capsid protein VP5.
Rad50_zn_hook (pfam04423)
  Rad50 zinc hook motif.
Rad50_zn_hook (pfam04423)
  Rad50 zinc hook motif.
HAUS2 (pfam15003)
  HAUS augmin-like complex subunit 2.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.
DUF342 (cl19219)
  Protein of unknown function (DUF342).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rad50 includes H.sapiens RAD50 and R.norvegicus Rad50.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 15 species)
Actinopterygii - bony fishes (13 transcripts, 8 species)
Aves - birds (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (23 transcripts, 17 species)
Liliopsida - monocots (7 transcripts, 7 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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