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HomoloGene:865. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ADAM10,  H.sapiens
ADAM metallopeptidase domain 10
    NP_001101.1
748 aa
   ADAM10,  P.troglodytes
ADAM metallopeptidase domain 10
    XP_001172405.1
748 aa
   ADAM10,  M.mulatta
ADAM metallopeptidase domain 10
    XP_001097016.1
748 aa
   ADAM10,  C.lupus
ADAM metallopeptidase domain 10
    XP_005638749.1
719 aa
   ADAM10,  B.taurus
ADAM metallopeptidase domain 10
    NP_776921.1
748 aa
   Adam10,  M.musculus
a disintegrin and metallopeptidase domain 10
    NP_031425.2
749 aa
   Adam10,  R.norvegicus
ADAM metallopeptidase domain 10
    NP_062127.1
749 aa
   ADAM10,  G.gallus
ADAM metallopeptidase domain 10
    NP_989592.2
749 aa
   adam10,  X.tropicalis
ADAM metallopeptidase domain 10
    NP_001037869.1
749 aa
   adam10a,  D.rerio
a disintegrin and metalloprotease domain 10a
    NP_001152786.1
751 aa
   AgaP_AGAP003070,  A.gambiae
AgaP_AGAP003070
    XP_312756.5
1683 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Marcello E, et al. J Clin Invest 123, 2523-38 (2013).
ADAM10 as a biomarker for Alzheimer's disease: a study with Brazilian elderly.
Manzine PR, et al. Dement Geriatr Cogn Disord 35, 58-66 (2013).
Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.
Tharmarajah G, et al. Pigment Cell Melanoma Res 25, 555-65 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pep_M12B_propep (pfam01562)
  Reprolysin family propeptide.
DUF4215 (pfam13948)
  Domain of unknown function (DUF4215).
Pep_M12B_propep (pfam01562)
  Reprolysin family propeptide.
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
Disintegrin (cl10507)
  Disintegrin.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Adam10 includes H.sapiens ADAM10 and R.norvegicus Adam10.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 7 species)
Aves - birds (3 transcripts, 3 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

 

 

 

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