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HomoloGene:1392. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COL6A2,  H.sapiens
collagen, type VI, alpha 2
    NP_001840.3
1019 aa
   COL6A2,  P.troglodytes
collagen, type VI, alpha 2
    XP_531504.3
1019 aa
   COL6A2,  M.mulatta
collagen, type VI, alpha 2
    XP_001099130.2
1029 aa
   Col6a2,  M.musculus
collagen, type VI, alpha 2
    NP_666119.1
1034 aa
   Col6a2,  R.norvegicus
collagen, type VI, alpha 2
    NP_001094211.1
1027 aa
   COL6A2,  G.gallus
collagen, type VI, alpha 2
    NP_990679.1
1022 aa
   LOC100145523,  X.tropicalis
uncharacterized LOC100145523
    NP_001120436.1
911 aa
   col6a2,  D.rerio
collagen, type VI, alpha 2
    XP_696164.2
1015 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Bethlem myopathy.
Ullrich congenital muscular dystrophy.



Publications
Articles associated with genes and sequences of this homology group.

Autosomal recessive myosclerosis myopathy is a collagen VI disorder.
Merlini L, et al. Neurology 71, 1245-53 (2008).
Ullrich scleroatonic muscular dystrophy is caused by recessive mutations in collagen type VI.
Camacho Vanegas O, et al. Proc Natl Acad Sci U S A 98, 7516-21 (2001).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
VWA (pfam00092)
  von Willebrand factor type A domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col6a2 includes H.sapiens COL6A2 and R.norvegicus Col6a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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