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HomoloGene:208. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MLH1,  H.sapiens
mutL homolog 1
    NP_000240.1
756 aa
   MLH1,  P.troglodytes
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
    XP_001170433.1
756 aa
   MLH1,  C.lupus
mutL homolog 1
    XP_534219.2
757 aa
   MLH1,  B.taurus
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
    NP_001069462.2
758 aa
   Mlh1,  M.musculus
mutL homolog 1 (E. coli)
    NP_081086.2
760 aa
   Mlh1,  R.norvegicus
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
    NP_112315.1
757 aa
   MLH1,  G.gallus
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
    XP_418828.1
757 aa
   mlh1,  X.tropicalis
mutL homolog 1
    XP_002933455.2
749 aa
   mlh1,  D.rerio
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
    NP_956953.1
724 aa
   Mlh1,  D.melanogaster
Mlh1
    NP_477022.1
664 aa
   AgaP_AGAP012192,  A.gambiae
AgaP_AGAP012192
    XP_320342.4
674 aa
   MLH1,  S.cerevisiae
MLH1
    NP_013890.1
769 aa
   KLLA0D09955g,  K.lactis
KLLA0D09955g
    XP_453504.1
724 aa
   AGOS_AFL199C,  E.gossypii
AGOS_AFL199C
    NP_985351.1
771 aa
   mlh1,  S.pombe
mlh1
    NP_596199.1
684 aa
   MGG_07121,  M.oryzae
MGG_07121
    XP_003715311.1
690 aa
   NCU08309,  N.crassa
NCU08309
    XP_962522.1
751 aa
   MLH1,  A.thaliana
MLH1
    NP_567345.2
737 aa
   Os01g0958900,  O.sativa
Os01g0958900
    NP_001045457.1
724 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cafe-au-lait spots with glioma or leukemia.
Muir-Torre syndrome.
Turcot syndrome with glioblastoma.
Colorectal cancer, hereditary nonpolyposis, type 2.



Publications
Articles associated with genes and sequences of this homology group.

Incidence of -93 MLH1 promoter polymorphism in familial and sporadic colorectal cancer.
Martínez-Urueña N, et al. Colorectal Dis 15, e118-23 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TopoII_MutL_Trans (cl02783)
  MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second ...
HATPase_c (cl00075)
  Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins.
TopoII_MutL_Trans (cl02783)
  MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mlh1 includes H.sapiens MLH1 and R.norvegicus Mlh1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (18 transcripts, 13 species)
Liliopsida - monocots (12 transcripts, 7 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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