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HomoloGene:1542. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GAB1,  H.sapiens
GRB2-associated binding protein 1
    NP_997006.1
724 aa
   GAB1,  P.troglodytes
GRB2-associated binding protein 1
    XP_517458.2
724 aa
   GAB1,  M.mulatta
GRB2-associated binding protein 1
    XP_001093044.1
724 aa
   GAB1,  C.lupus
GRB2-associated binding protein 1
    XP_005631825.1
721 aa
   GAB1,  B.taurus
GRB2-associated binding protein 1
    NP_001094671.1
694 aa
   Gab1,  M.musculus
growth factor receptor bound protein 2-associated protein 1
    NP_067331.2
695 aa
   Gab1,  R.norvegicus
GRB2-associated binding protein 1
    NP_001101914.1
694 aa
   GAB1,  G.gallus
GRB2-associated binding protein 1
    XP_001232602.1
721 aa
   gab1,  X.tropicalis
GRB2-associated binding protein 1
    XP_002940124.2
903 aa
   gab1,  D.rerio
GRB2-associated binding protein 1
    NP_998522.1
405 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Functional characterization of cancer-associated Gab1 mutations.
Ortiz-Padilla C, et al. Oncogene 32, 2696-702 (2013).
Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.
Zhao J, et al. Arterioscler Thromb Vasc Biol 31, 1016-23 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl17171)
  Pleckstrin homology-like domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gab1 includes H.sapiens GAB1 and R.norvegicus Gab1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

 

 

 

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