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HomoloGene:8372. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DMGDH,  H.sapiens
dimethylglycine dehydrogenase
    NP_037523.2
866 aa
   DMGDH,  P.troglodytes
dimethylglycine dehydrogenase
    XP_526883.2
866 aa
   DMGDH,  C.lupus
dimethylglycine dehydrogenase
    XP_005618235.1
840 aa
   DMGDH,  B.taurus
dimethylglycine dehydrogenase
    NP_001192474.1
866 aa
   Dmgdh,  M.musculus
dimethylglycine dehydrogenase precursor
    NP_083048.1
869 aa
   Dmgdh,  R.norvegicus
dimethylglycine dehydrogenase
    NP_620802.2
857 aa
   DMGDH,  G.gallus
dimethylglycine dehydrogenase
    XP_003643002.1
868 aa
   dmgdh,  X.tropicalis
dimethylglycine dehydrogenase
    XP_002940239.2
870 aa
   dmgdh,  D.rerio
dimethylglycine dehydrogenase
    XP_002665871.2
899 aa
   Y37E3.17,  C.elegans
Y37E3.17
    NP_001021746.1
837 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dimethylglycine dehydrogenase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Structure and analysis of the human dimethylglycine dehydrogenase gene.
Binzak BA, et al. Mol Genet Metab 69, 181-7 (2000).
Identification of folate binding protein of mitochondria as dimethylglycine dehydrogenase.
Wittwer AJ & Wagner C. Proc Natl Acad Sci U S A 77, 4484-8 (1980).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DAO (pfam01266)
  FAD dependent oxidoreductase.
GCV_T_C (pfam08669)
  Glycine cleavage T-protein C-terminal barrel domain.
DadA (COG0665)
  Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].
SoxG (cl01893)
  Sarcosine oxidase, gamma subunit family.
GCV_T_C (pfam08669)
  Glycine cleavage T-protein C-terminal barrel domain.
GCV_T (cl01893)
  Aminomethyltransferase folate-binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dmgdh includes H.sapiens DMGDH and R.norvegicus Dmgdh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

 

 

 

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