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HomoloGene:8014. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BACE1,  H.sapiens
beta-site APP-cleaving enzyme 1
    NP_036236.1
501 aa
   BACE1,  P.troglodytes
beta-site APP-cleaving enzyme 1
    XP_001158428.1
501 aa
   BACE1,  M.mulatta
beta-site APP-cleaving enzyme 1
    XP_001094263.1
501 aa
   BACE1,  C.lupus
beta-site APP-cleaving enzyme 1
    XP_546508.3
392 aa
   BACE1,  B.taurus
beta-site APP-cleaving enzyme 1
    NP_001039996.1
501 aa
   Bace1,  M.musculus
beta-site APP cleaving enzyme 1
    NP_035922.4
501 aa
   Bace1,  R.norvegicus
beta-site APP cleaving enzyme 1
    NP_062077.1
501 aa
   BACE1,  G.gallus
beta-site APP-cleaving enzyme 1
    XP_417908.3
497 aa
   bace1,  X.tropicalis
beta-site APP-cleaving enzyme 1
    NP_001072485.1
502 aa
   bace1,  D.rerio
beta-site APP-cleaving enzyme 1
    NP_991267.1
505 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Transcriptional and post-transcriptional regulation of β-secretase.
Tamagno E, et al. IUBMB Life 64, 943-50 (2012).
Splice variants of the Alzheimer's disease beta-secretase, BACE1.
Holsinger RM, et al. Neurogenetics 14, 1-9 (2013).
BACE1 levels are elevated in congestive heart failure.
Nural-Guvener HF, et al. Neurosci Lett 532, 7-11 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
pepsin_retropepsin_like (cl11403)
  Cellular and retroviral pepsin-like aspartate proteases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bace1 includes H.sapiens BACE1 and R.norvegicus Bace1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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