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HomoloGene:1576. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GRB2,  H.sapiens
growth factor receptor-bound protein 2
    NP_002077.1
217 aa
   GRB2,  P.troglodytes
growth factor receptor-bound protein 2
    NP_001233546.1
217 aa
   GRB2,  C.lupus
growth factor receptor-bound protein 2
    XP_540431.2
217 aa
   GRB2,  B.taurus
growth factor receptor-bound protein 2
    NP_001029802.1
217 aa
   Grb2,  M.musculus
growth factor receptor bound protein 2
    NP_032189.1
217 aa
   Grb2,  R.norvegicus
growth factor receptor bound protein 2
    NP_110473.2
217 aa
   GRB2,  G.gallus
growth factor receptor-bound protein 2
    NP_989742.1
217 aa
   grb2,  X.tropicalis
grb2 protein
    NP_001008130.1
229 aa
   grb2b,  D.rerio
growth factor receptor-bound protein 2b
    NP_998200.1
217 aa
   drk,  D.melanogaster
downstream of receptor kinase
    NP_725306.1
211 aa
   AgaP_AGAP011768,  A.gambiae
AgaP_AGAP011768
    XP_320742.3
211 aa
   sem-5,  C.elegans
sem-5
    NP_509342.1
228 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Grb2, a double-edged sword of receptor tyrosine kinase signaling.
Belov AA & Mohammadi M. Sci Signal 5, pe49 (2012).
Grb2 mediates semaphorin-4D-dependent RhoA inactivation.
Sun T, et al. J Cell Sci 125, 3557-67 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Grb2 includes H.sapiens GRB2 and R.norvegicus Grb2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (16 transcripts, 11 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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