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HomoloGene:11210. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NYX,  H.sapiens
nyctalopin
    NP_072089.1
481 aa
   NYX,  P.troglodytes
nyctalopin
    XP_001138632.2
481 aa
   SLRN,  M.mulatta
nyctalopin-like
    XP_001087613.1
476 aa
   NYX,  C.lupus
nyctalopin
    XP_005641316.1
474 aa
   NYX,  B.taurus
nyctalopin
    XP_005228361.1
483 aa
   Nyx,  M.musculus
nyctalopin
    NP_775591.1
476 aa
   Nyx,  R.norvegicus
nyctalopin
    NP_001094437.1
476 aa
   NYX,  G.gallus
nyctalopin
    XP_004934667.1
473 aa
   nyx,  X.tropicalis
nyctalopin
    XP_002932845.2
468 aa
   nyx,  D.rerio
nyctalopin
    NP_001071085.1
469 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Night blindness, congenital stationary, type 1.



Publications
Articles associated with genes and sequences of this homology group.

A novel missense mutation in the NYX gene associated with high myopia.
Yip SP, et al. Ophthalmic Physiol Opt 33, 346-53 (2013).
Topological analysis of small leucine-rich repeat proteoglycan nyctalopin.
Bojang P Jr & Gregg RG. PLoS One 7, e33137 (2012).
A common NYX mutation in Flemish patients with X linked CSNB.
Leroy BP, et al. Br J Ophthalmol 93, 692-6 (2009).
High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect.
Pardue MT, et al. Invest Ophthalmol Vis Sci 49, 706-12 (2008).
CSNB1 in Chinese families associated with novel mutations in NYX.
Xiao X, et al. J Hum Genet 51, 634-40 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_TYP (cl15310)
  Leucine-rich repeats, typical (most populated) subfamily.
LRR_8 (pfam13855)
  Leucine rich repeat.
LRRCT (smart00082)
  Leucine rich repeat C-terminal domain.
LRRNT (cl02423)
  Leucine rich repeat N-terminal domain.
LRR_8 (pfam13855)
  Leucine rich repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nyx includes H.sapiens NYX and R.norvegicus Nyx.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (3 transcripts, 3 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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