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HomoloGene:3828. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   E2F1,  H.sapiens
E2F transcription factor 1
437 aa
   E2F1,  P.troglodytes
E2F transcription factor 1
437 aa
   E2F1,  M.mulatta
E2F transcription factor 1
437 aa
   E2F1,  C.lupus
E2F transcription factor 1
436 aa
   E2F1,  B.taurus
E2F transcription factor 1
437 aa
   E2f1,  M.musculus
E2F transcription factor 1
430 aa
   E2f1,  R.norvegicus
E2F transcription factor 1
432 aa
   E2F1,  G.gallus
E2F transcription factor 1
403 aa
   e2f1,  X.tropicalis
E2F transcription factor 1
428 aa
   LOC101885420,  D.rerio
transcription factor E2F1-like
431 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

E2F-1 lacking the transcriptional activity domain induces autophagy.
Garcia-Garcia A, et al. Cancer Biol Ther 13, 1091-101 (2012).
The role of the E2F1 transcription factor in the innate immune response to systemic LPS.
Warg LA, et al. Am J Physiol Lung Cell Mol Physiol 303, L391-400 (2012).
E2F1-dependent methyl cap formation requires RNA pol II phosphorylation.
Aregger M & Cowling VH. Cell Cycle 11, 2146-8 (2012).
E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma.
Palaiologou M, et al. Virchows Arch 460, 439-46 (2012).
The dark side of E2F1: in transit beyond apoptosis.
Engelmann D & PĆ¼tzer BM. Cancer Res 72, 571-5 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
E2F_TDP (pfam02319)
  E2F/DP family winged-helix DNA-binding domain.
E2F_TDP (pfam02319)
  E2F/DP family winged-helix DNA-binding domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus E2f1 includes H.sapiens E2F1 and R.norvegicus E2f1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)




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