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HomoloGene:20716. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   USP4,  H.sapiens
ubiquitin specific peptidase 4 (proto-oncogene)
    NP_003354.2
963 aa
   USP4,  P.troglodytes
ubiquitin specific peptidase 4 (proto-oncogene)
    XP_001163445.1
962 aa
   USP4,  M.mulatta
ubiquitin specific peptidase 4 (proto-oncogene)
    XP_002802844.1
935 aa
   USP4,  C.lupus
ubiquitin specific peptidase 4 (proto-oncogene)
    XP_003432923.1
917 aa
   USP4,  B.taurus
ubiquitin specific peptidase 4 (proto-oncogene)
    NP_001093789.1
963 aa
   Usp4,  M.musculus
ubiquitin specific peptidase 4 (proto-oncogene)
    NP_035808.2
962 aa
   Usp4,  R.norvegicus
ubiquitin specific peptidase 4 (proto-oncogene)
    NP_001128484.1
961 aa
   USP4,  G.gallus
ubiquitin specific peptidase 4 (proto-oncogene)
    NP_001006134.1
964 aa
   usp4,  X.tropicalis
ubiquitin specific peptidase 4 (proto-oncogene)
    XP_002936515.1
975 aa
   usp4,  D.rerio
ubiquitin specific protease 4 (proto-oncogene)
    XP_002662556.2
1009 aa
   H34C03.2,  C.elegans
H34C03.2
    NP_501035.1
900 aa
   UBP5,  A.thaliana
UBP5
    NP_565944.1
924 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.
Wada K, et al. Biochem Biophys Res Commun 339, 731-6 (2006).
Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function.
Di Donato F, et al. Int J Biochem Cell Biol 33, 924-34 (2001).
The Unp proto-oncogene encodes a nuclear protein.
Gupta K, et al. Oncogene 9, 1729-31 (1994).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_C19 (cl02553)
  Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
USP7_C2 (pfam14533)
  Ubiquitin-specific protease C-terminal.
Ubiquitin_3 (pfam14836)
  Ubiquitin-like domain.
Peptidase_C19 (cl02553)
  Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
DUSP (cl12116)
  DUSP domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Usp4 includes H.sapiens USP4 and R.norvegicus Usp4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (12 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (27 transcripts, 18 species)
Liliopsida - monocots (8 transcripts, 7 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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