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HomoloGene:3100. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   AIFM1,  H.sapiens
apoptosis-inducing factor, mitochondrion-associated, 1
    NP_004199.1
613 aa
   AIFM1,  P.troglodytes
apoptosis-inducing factor, mitochondrion-associated, 1
    XP_003317723.1
706 aa
   AIFM1,  M.mulatta
apoptosis-inducing factor, mitochondrion-associated, 1
    XP_001092025.1
609 aa
   AIFM1,  C.lupus
apoptosis-inducing factor, mitochondrion-associated, 1
    XP_538170.2
613 aa
   AIFM1,  B.taurus
apoptosis-inducing factor, mitochondrion-associated, 1
    NP_001179913.1
613 aa
   Aifm1,  M.musculus
apoptosis-inducing factor, mitochondrion-associated 1
    NP_036149.1
612 aa
   Aifm1,  R.norvegicus
apoptosis-inducing factor, mitochondrion-associated 1
    NP_112646.1
612 aa
   AIFM1,  G.gallus
apoptosis-inducing factor, mitochondrion-associated, 1
    NP_001007491.1
591 aa
   aifm1,  X.tropicalis
apoptosis-inducing factor, mitochondrion-associated, 1
    NP_001017244.1
636 aa
   aifm1,  D.rerio
apoptosis-inducing factor, mitochondrion-associated 1
    NP_956396.2
613 aa
   AIF,  D.melanogaster
Apoptosis inducing factor
    NP_001259907.1
738 aa
   AgaP_AGAP008044,  A.gambiae
AgaP_AGAP008044
    XP_317418.4
719 aa
   wah-1,  C.elegans
wah-1
    NP_499564.2
700 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Combined oxidative phosphorylation deficiency 6.



Publications
Articles associated with genes and sequences of this homology group.

Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
Rinaldi C, et al. Am J Hum Genet 91, 1095-102 (2012).
An alternative import pathway of AIF to the mitochondria.
Chiang SF, et al. Int J Mol Med 29, 365-72 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pyr_redox (pfam00070)
  Pyridine nucleotide-disulphide oxidoreductase.
Pyr_redox (pfam00070)
  Pyridine nucleotide-disulphide oxidoreductase.
AIF_C (pfam14721)
  Apoptosis-inducing factor, mitochondrion-associated, C-term.
AIF-MLS (pfam14962)
  Mitochondria Localisation Sequence.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aifm1 includes H.sapiens AIFM1 and R.norvegicus Aifm1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 15 species)
Actinopterygii - bony fishes (13 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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