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HomoloGene:21249. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PIK3CA,  H.sapiens
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    NP_006209.2
1068 aa
   PIK3CA,  P.troglodytes
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    XP_001167506.1
1068 aa
   PIK3CA,  M.mulatta
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    XP_001109162.1
1068 aa
   PIK3CA,  C.lupus
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    XP_545208.2
1068 aa
   PIK3CA,  B.taurus
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    NP_776999.1
1068 aa
   Pik3ca,  M.musculus
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
    NP_032865.2
1068 aa
   Pik3ca,  R.norvegicus
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    NP_596890.2
1068 aa
   PIK3CA,  G.gallus
phosphoinositide-3-kinase, catalytic, alpha polypeptide
    NP_001004410.1
1068 aa
   pik3ca,  X.tropicalis
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    NP_001119972.1
1065 aa
   LOC561737,  D.rerio
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like
    XP_690235.2
1069 aa
   LOC100334726,  D.rerio
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like
    XP_005174483.1
1069 aa
   age-1,  C.elegans
age-1
    NP_496462.2
1182 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer.
Colorectal cancer.
Ovarian cancer.



Publications
Articles associated with genes and sequences of this homology group.

PIK3CA activating mutations in facial infiltrating lipomatosis.
Maclellan RA, et al. Plast Reconstr Surg 133, 12e-9e (2014).
[PIK3CA mutations in the most common types of cancer].
Chomczyk MA & Czajka P. Postepy Biochem 59, 280-4 (2013).
PIK3CA-Related Segmental Overgrowth
Mirzaa G, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PI3K_p85B (cl02483)
  PI3-kinase family, p85-binding domain.
PI3K_rbd (pfam00794)
  PI3-kinase family, ras-binding domain.
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
PI3Ka (cl00271)
  Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
PI3K_rbd (cl02484)
  PI3-kinase family, ras-binding domain.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pik3ca includes H.sapiens PIK3CA.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 9 species)
Mammalia - mammals (13 transcripts, 10 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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