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HomoloGene:2698. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IKBKG,  H.sapiens
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    NP_001093326.2
487 aa
   LOC100610002,  P.troglodytes
NF-kappa-B essential modulator-like
    XP_003317847.1
368 aa
   IKBKG,  M.mulatta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    XP_002806492.1
487 aa
   IKBKG,  C.lupus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    XP_005642095.1
457 aa
   IKBKG,  B.taurus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    XP_005227781.1
535 aa
   Ikbkg,  M.musculus
inhibitor of kappaB kinase gamma
    NP_001154894.1
424 aa
   Ikbkg,  R.norvegicus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    NP_954534.1
412 aa
   ikbkg,  X.tropicalis
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    NP_001120221.1
506 aa
   ikbkg,  D.rerio
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    NP_001014366.1
586 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Invasive pneumococcal disease, recurrent isolated, 2.
Ectodermal dysplasia, hypohidrotic, with immune deficiency.
Ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency.
Immunodeficiency, isolated.
Atypical mycobacteriosis, familial.
Incontinentia pigmenti, type II.



Publications
Articles associated with genes and sequences of this homology group.

Novel Phosphorylations of IKKγ/NEMO.
Lee SH, et al. MBio 3, e00411-12 (2012).
Incontinentia pigmenti with NEMO mutation in a Japanese family.
Okita M, et al. J Dermatol 39, 940-1 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NEMO (pfam11577)
  NF-kappa-B essential modulator NEMO.
UBAN (cd09803)
  polyubiquitin binding domain of NEMO and related proteins.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ikbkg includes H.sapiens IKBKG and R.norvegicus Ikbkg.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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