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HomoloGene:7813. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   LEF1,  H.sapiens
lymphoid enhancer-binding factor 1
399 aa
   LEF1,  P.troglodytes
lymphoid enhancer-binding factor 1
399 aa
   LEF1,  C.lupus
lymphoid enhancer-binding factor 1
400 aa
   LEF1,  B.taurus
lymphoid enhancer-binding factor 1
399 aa
   Lef1,  M.musculus
lymphoid enhancer binding factor 1
397 aa
   Lef1,  R.norvegicus
lymphoid enhancer binding factor 1
397 aa
   LEF1,  G.gallus
lymphoid enhancer-binding factor 1
369 aa
   lef1,  X.tropicalis
lymphoid enhancer-binding factor 1
372 aa
   lef1,  D.rerio
lymphocyte enhancer binding factor 1
365 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Sebaceous tumors, somatic.

Articles associated with genes and sequences of this homology group.

Genetic mapping of agenesis of the third molars in mice.
Shimizu T, et al. Biochem Genet 51, 728-36 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CTNNB1_binding (pfam08347)
  N-terminal CTNNB1 binding.
CTNNB1_binding (pfam08347)
  N-terminal CTNNB1 binding.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lef1 includes H.sapiens LEF1 and R.norvegicus Lef1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)




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