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HomoloGene:56763. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PDE11A,  H.sapiens
phosphodiesterase 11A
933 aa
   PDE11A,  M.mulatta
phosphodiesterase 11A
933 aa
   PDE11A,  C.lupus
phosphodiesterase 11A
925 aa
   PDE11A,  B.taurus
phosphodiesterase 11A
926 aa
   Pde11a,  M.musculus
phosphodiesterase 11A
933 aa
   Pde11a,  R.norvegicus
phosphodiesterase 11A
935 aa
   PDE11A,  G.gallus
phosphodiesterase 11A
895 aa
   pde11a,  X.tropicalis
phosphodiesterase 11A
892 aa
   pde11a,  D.rerio
phosphodiesterase 11a
894 aa
   Pde6,  D.melanogaster
Phosphodiesterase 6
1118 aa
   AgaP_AGAP004119,  A.gambiae
1152 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Pigmented nodular adrenocortical disease, primary, 2.

Articles associated with genes and sequences of this homology group.

PDE11A associations with asthma: results of a genome-wide association scan.
DeWan AT, et al. J Allergy Clin Immunol 126, 871-873.e9 (2010).
Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients.
Peverelli E, et al. Eur J Endocrinol 161, 687-94 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PDEase_I (pfam00233)
  3'5'-cyclic nucleotide phosphodiesterase.
HDc (cl17215)
  Metal dependent phosphohydrolases with conserved 'HD' motif.
GAF (cl17456)
  This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pde11a includes H.sapiens PDE11A and R.norvegicus Pde11a.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (6 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (9 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Gastropoda - gastropods (5 transcripts, 2 species)

Chromadorea - nematodes (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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