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HomoloGene:37954. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HGS,  H.sapiens
hepatocyte growth factor-regulated tyrosine kinase substrate
    NP_004703.1
777 aa
   HGS,  P.troglodytes
hepatocyte growth factor-regulated tyrosine kinase substrate
    XP_511742.4
944 aa
   HGS,  M.mulatta
hepatocyte growth factor-regulated tyrosine kinase substrate
    XP_001111673.1
777 aa
   HGS,  C.lupus
hepatocyte growth factor-regulated tyrosine kinase substrate
    XP_005624060.1
782 aa
   HGS,  B.taurus
hepatocyte growth factor-regulated tyrosine kinase substrate
    NP_001039554.1
776 aa
   Hgs,  M.musculus
HGF-regulated tyrosine kinase substrate
    NP_001152800.1
776 aa
   Hgs,  R.norvegicus
hepatocyte growth factor-regulated tyrosine kinase substrate
    NP_062260.2
771 aa
   HGS,  G.gallus
hepatocyte growth factor-regulated tyrosine kinase substrate
    XP_426233.3
775 aa
   hgs,  X.tropicalis
hepatocyte growth factor-regulated tyrosine kinase substrate
    NP_001016513.1
755 aa
   hgs,  D.rerio
hepatocyte growth factor-regulated tyrosine kinase substrate
    NP_956162.1
447 aa
   Hrs,  D.melanogaster
Hepatocyte growth factor regulated tyrosine kinase substrate
    NP_525099.3
760 aa
   AgaP_AGAP008887,  A.gambiae
AgaP_AGAP008887
    XP_319634.4
731 aa
   hgrs-1,  C.elegans
hgrs-1
    NP_501375.2
729 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

[Role of the Drosophila melanogaster hrs gene in wing formation].
Kopyl SA, et al. Genetika 48, 1039-45 (2012).
The biogenesis of multivesicular endosomes.
Gruenberg J & Stenmark H. Nat Rev Mol Cell Biol 5, 317-23 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Hrs_helical (pfam12210)
  Hepatocyte growth factor-regulated tyrosine kinase substrate.
FYVE (pfam01363)
  FYVE zinc finger.
dsDNA_bind (cl00928)
  Double-stranded DNA-binding domain.
Caudal_act (pfam04731)
  Caudal like protein activation region.
YlqD (pfam11068)
  YlqD protein.
VHS_ENTH_ANTH (cl02544)
  VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
FYVE (cl17764)
  FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hgs includes H.sapiens HGS and R.norvegicus Hgs.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 10 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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