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HomoloGene:2845. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   RGS9,  H.sapiens
regulator of G-protein signaling 9
674 aa
   RGS9,  P.troglodytes
regulator of G-protein signaling 9
674 aa
   RGS9,  M.mulatta
regulator of G-protein signaling 9
642 aa
   RGS9,  C.lupus
regulator of G-protein signaling 9
677 aa
   Rgs9,  M.musculus
regulator of G-protein signaling 9
675 aa
   Rgs9,  R.norvegicus
regulator of G-protein signaling 9
677 aa
   RGS9,  G.gallus
regulator of G-protein signaling 9
645 aa
   rgs9b,  D.rerio
regulator of G-protein signaling 9b
661 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.


Articles associated with genes and sequences of this homology group.

Biology and functions of the RGS9 isoforms.
Martemyanov KA & Arshavsky VY. Prog Mol Biol Transl Sci 86, 205-27 (2009).
Distribution of RGS9-2 in neurons of the mouse striatum.
Mancuso JJ, et al. J Neurochem 112, 651-61 (2010).
RGS9 concentration matters in rod phototransduction.
Burns ME & Pugh EN Jr. Biophys J 97, 1538-47 (2009).
Functional comparison of RGS9 splice isoforms in a living cell.
Martemyanov KA, et al. Proc Natl Acad Sci U S A 105, 20988-93 (2008).
Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia.
Liou YJ, et al. Am J Med Genet B Neuropsychiatr Genet 150B, 239-42 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GGL (cl00069)
  G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors.
DEP (cl02442)
  DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
RGS (cl02565)
  Regulator of G protein signaling (RGS) domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rgs9 includes H.sapiens RGS9 and R.norvegicus Rgs9.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (7 transcripts, 6 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Turbellaria - flatworms (1 transcript, 1 species)




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