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HomoloGene:40891. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EIF2AK4,  H.sapiens
eukaryotic translation initiation factor 2 alpha kinase 4
    NP_001013725.2
1649 aa
   EIF2AK4,  P.troglodytes
eukaryotic translation initiation factor 2 alpha kinase 4
    XP_001140245.1
1649 aa
   EIF2AK4,  M.mulatta
eukaryotic translation initiation factor 2 alpha kinase 4
    XP_002804763.1
714 aa
   EIF2AK4,  C.lupus
eukaryotic translation initiation factor 2 alpha kinase 4
    XP_535431.3
1651 aa
   EIF2AK4,  B.taurus
eukaryotic translation initiation factor 2 alpha kinase 4
    XP_002690831.1
1649 aa
   Eif2ak4,  M.musculus
eukaryotic translation initiation factor 2 alpha kinase 4
    NP_038747.2
1648 aa
   Eif2ak4,  R.norvegicus
eukaryotic translation initiation factor 2 alpha kinase 4
    NP_001099214.2
1649 aa
   EIF2AK4,  G.gallus
eukaryotic translation initiation factor 2 alpha kinase 4
    XP_004941777.1
1656 aa
   eif2ak4,  X.tropicalis
eukaryotic translation initiation factor 2 alpha kinase 4
    NP_001243855.1
1668 aa
   eif2ak4,  D.rerio
eukaryotic translation initiation factor 2 alpha kinase 4
    XP_002667149.3
1552 aa
   Gcn2,  D.melanogaster
Gcn2
    NP_001263141.1
1589 aa
   AgaP_AGAP012368,  A.gambiae
AgaP_AGAP012368
    XP_320188.4
1484 aa
   gcn-2,  C.elegans
gcn-2
    NP_001254370.1
1699 aa
   GCN2,  S.cerevisiae
GCN2
    NP_010569.3
1659 aa
   KLLA0C10802g,  K.lactis
KLLA0C10802g
    XP_452681.1
1672 aa
   AGOS_AAL083W,  E.gossypii
AGOS_AAL083W
    NP_982459.1
1698 aa
   gcn2,  S.pombe
gcn2
    NP_595991.2
1576 aa
   MGG_08643,  M.oryzae
MGG_08643
    XP_003711074.1
1679 aa
   NCU01187,  N.crassa
NCU01187
    XP_961553.1
1646 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Activation of GCN2 upon HIV-1 infection and inhibition of translation.
Cosnefroy O, et al. Cell Mol Life Sci 70, 2411-21 (2013).
The eIF2α kinases: their structures and functions.
Donnelly N, et al. Cell Mol Life Sci 70, 3493-511 (2013).
New functions of protein kinase Gcn2 in yeast and mammals.
Murguía JR & Serrano R. IUBMB Life 64, 971-4 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
RWD (pfam05773)
  RWD domain.
HGTP_anticodon2 (pfam12745)
  Anticodon binding domain of tRNAs.
HisS (COG0124)
  Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].
L12P_arch (TIGR03685)
  50S ribosomal protein L12P.
class_II_aaRS-like_core (cl00268)
  Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
HGTP_anticodon2 (pfam12745)
  Anticodon binding domain of tRNAs.
HGTP_anticodon (cl00266)
  HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
class_II_aaRS-like_core (cl00268)
  Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it ...
RWD (cl02687)
  RWD domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eif2ak4 includes H.sapiens EIF2AK4 and R.norvegicus Eif2ak4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 9 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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