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HomoloGene:40757. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NR1I2,  H.sapiens
nuclear receptor subfamily 1, group I, member 2
    NP_071285.1
473 aa
   NR1I2,  P.troglodytes
nuclear receptor subfamily 1, group I, member 2
    XP_001164074.1
473 aa
   NR1I2,  M.mulatta
nuclear receptor subfamily 1, group I, member 2
    NP_001028054.3
434 aa
   NR1I2,  B.taurus
nuclear receptor subfamily 1, group I, member 2
    NP_001096696.1
420 aa
   Nr1i2,  M.musculus
nuclear receptor subfamily 1, group I, member 2
    NP_035066.1
431 aa
   Nr1i2,  R.norvegicus
nuclear receptor subfamily 1, group I, member 2
    NP_443212.1
431 aa
   nr1i2,  X.tropicalis
nuclear receptor subfamily 1, group I, member 2
    NP_001091887.1
391 aa
   nr1i2,  D.rerio
nuclear receptor subfamily 1, group I, member 2
    NP_001092087.1
430 aa
   Hr96,  D.melanogaster
Hormone receptor-like in 96
    NP_524493.1
723 aa
   AgaP_AGAP004224,  A.gambiae
AgaP_AGAP004224
    XP_313130.5
926 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Poulton EJ, et al. Toxicol Appl Pharmacol 266, 122-31 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nr1i2 includes H.sapiens NR1I2 and R.norvegicus Nr1i2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)

 

 

 

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