Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:2888. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ASAP2,  H.sapiens
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    NP_003878.1
1006 aa
   ASAP2,  P.troglodytes
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_515290.3
990 aa
   ASAP2,  M.mulatta
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_001088227.2
1204 aa
   ASAP2,  C.lupus
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_005630157.1
1012 aa
   ASAP2,  B.taurus
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_002691576.2
991 aa
   Asap2,  M.musculus
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    NP_001128664.1
1000 aa
   Asap2,  R.norvegicus
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_006240060.1
896 aa
   ASAP2,  G.gallus
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_001231632.3
1004 aa
   asap2,  X.tropicalis
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    XP_002935078.2
1025 aa
   asap2a,  D.rerio
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2a
    NP_001038672.1
991 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages.
Seuter S, et al. J Steroid Biochem Mol Biol 144 Pt A, 12-8 (2014).
A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function.
Hashimoto S, et al. J Biol Chem 279, 37677-84 (2004).
Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I.
Kim H & Lee Y. Biochem Biophys Res Commun 289, 513-8 (2001).
Regulation of Bin1 SH3 domain binding by phosphoinositides.
Kojima C, et al. EMBO J 23, 4413-22 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ArfGap (pfam01412)
  Putative GTPase activating protein for Arf.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Asap2 includes H.sapiens ASAP2 and R.norvegicus Asap2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (24 transcripts, 8 species)
Mammalia - mammals (10 transcripts, 9 species)
Aves - birds (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

Write to the Help Desk