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HomoloGene:30970. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   WAS,  H.sapiens
Wiskott-Aldrich syndrome
    NP_000368.1
502 aa
   LOC714474,  M.mulatta
wiskott-Aldrich syndrome protein-like
    XP_001104246.2
663 aa
   WAS,  C.lupus
Wiskott-Aldrich syndrome
    XP_548986.2
503 aa
   Was,  M.musculus
Wiskott-Aldrich syndrome homolog (human)
    NP_033541.1
520 aa
   Was,  R.norvegicus
Wiskott-Aldrich syndrome
    NP_001101718.1
355 aa
   wasa,  D.rerio
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
    XP_699919.5
630 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Neutropenia, severe congenital, X-linked.
Wiskott-Aldrich syndrome.
Thrombocytopenia, X-linked.
Thrombocytopenia, X-linked, intermittent.



Publications
Articles associated with genes and sequences of this homology group.

Colitis and colon cancer in WASP-deficient mice require helicobacter species.
Nguyen DD, et al. Inflamm Bowel Dis 19, 2041-50 (2013).
Two cases of Wiskott-Aldrich syndrome in neonates due to gene mutations.
Zhang S, et al. Fetal Pediatr Pathol 32, 312-5 (2013).
Detection of six novel mutations in WASP gene in fifteen Iranian Wiskott-Aldrich patients.
Safaei S, et al. Iran J Allergy Asthma Immunol 11, 345-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
WH2 (smart00246)
  Wiskott Aldrich syndrome homology region 2.
CRIB (cl00113)
  PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
WH2 (pfam02205)
  WH2 motif.
CRIB (cl00113)
  PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Was includes H.sapiens WAS.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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