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HomoloGene:21130. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ABCA1,  H.sapiens
ATP-binding cassette, sub-family A (ABC1), member 1
    NP_005493.2
2261 aa
   ABCA1,  P.troglodytes
ATP-binding cassette, sub-family A (ABC1), member 1
    XP_001138040.1
2261 aa
   ABCA1,  C.lupus
ATP-binding cassette, sub-family A (ABC1), member 1
    XP_005626946.1
2262 aa
   ABCA1,  B.taurus
ATP-binding cassette, sub-family A (ABC1), member 1
    NP_001019864.1
2261 aa
   Abca1,  M.musculus
ATP-binding cassette, sub-family A (ABC1), member 1
    NP_038482.3
2261 aa
   Abca1,  R.norvegicus
ATP-binding cassette, subfamily A (ABC1), member 1
    NP_835196.1
2201 aa
   ABCA1,  G.gallus
ATP-binding cassette, sub-family A (ABC1), member 1
    NP_989476.1
2260 aa
   abca1,  X.tropicalis
ATP-binding cassette, sub-family A (ABC1), member 1
    XP_002934028.2
2264 aa
   abca1b,  D.rerio
ATP-binding cassette, sub-family A (ABC1), member 1B
    NP_001108058.2
2271 aa
   abca1a,  D.rerio
ATP-binding cassette, sub-family A (ABC1), member 1A
    XP_005160198.1
2268 aa
   abt-2,  C.elegans
abt-2
    NP_490949.3
2146 aa
   ABCA1,  A.thaliana
ABCA1
    NP_850354.2
1882 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Coronary artery disease in familial hypercholesterolemia, protection against.
Tangier disease.
HDL deficiency, familial.



Publications
Articles associated with genes and sequences of this homology group.

ABCA1 influences neuroinflammation and neuronal death.
Karasinska JM, et al. Neurobiol Dis 54, 445-55 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ABC2_membrane_3 (pfam12698)
  ABC-2 family transporter protein.
ABC2_membrane_3 (pfam12698)
  ABC-2 family transporter protein.
DUF4162 (pfam13732)
  Domain of unknown function (DUF4162).
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Abca1 includes H.sapiens ABCA1 and R.norvegicus Abca1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (27 transcripts, 5 species)
Mammalia - mammals (16 transcripts, 9 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (28 transcripts, 19 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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