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HomoloGene:187. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KIT,  H.sapiens
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_000213.1
976 aa
   KIT,  P.troglodytes
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    XP_517285.3
972 aa
   KIT,  M.mulatta
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    XP_001089071.1
976 aa
   KIT,  C.lupus
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_001003181.1
975 aa
   KIT,  B.taurus
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_001159956.1
977 aa
   Kit,  M.musculus
kit oncogene
    NP_001116205.1
979 aa
   Kit,  R.norvegicus
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_071600.1
978 aa
   KIT,  G.gallus
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_989692.1
960 aa
   kit,  X.tropicalis
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_001135545.1
956 aa
   kita,  D.rerio
kit receptor a
    NP_571128.1
976 aa
   kitb,  D.rerio
kit receptor b
    NP_001137390.1
957 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mast cell leukemia.
Mastocytosis with associated hematologic disorder.
Piebaldism.
piebald trait.
Germ cell tumors.
Leukemia, acute myeloid.
Gastrointestinal stromal tumor, somatic.



Publications
Articles associated with genes and sequences of this homology group.

KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
Cavnar MJ, et al. J Exp Med 210, 2873-86 (2013).
Diagnosis and treatment of KIT-mutant metastatic melanoma.
Lyle M & Long GV. J Clin Oncol 31, 3176-81 (2013).
[Identification of novel KIT gene mutations in two Chinese families with piebaldism].
He WB, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 385-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ig_2 (pfam13895)
  Immunoglobulin domain.
IG_like (smart00410)
  Immunoglobulin like.
Pkinase_Tyr (pfam07714)
  Protein tyrosine kinase.
Ig (cl11960)
  Immunoglobulin domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kit includes H.sapiens KIT and R.norvegicus Kit.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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