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HomoloGene:4706. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PRPF8,  H.sapiens
pre-mRNA processing factor 8
    NP_006436.3
2335 aa
   PRPF8,  M.mulatta
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
    XP_001117328.1
2324 aa
   PRPF8,  C.lupus
pre-mRNA processing factor 8
    XP_854384.1
2335 aa
   PRPF8,  B.taurus
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
    NP_001099108.1
2335 aa
   Prpf8,  M.musculus
pre-mRNA processing factor 8
    NP_619600.2
2335 aa
   Prpf8,  R.norvegicus
pre-mRNA processing factor 8
    NP_001178519.1
2335 aa
   PRPF8,  G.gallus
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
    XP_415805.2
2335 aa
   prpf8,  X.tropicalis
pre-mRNA processing factor 8
    XP_002936105.1
2335 aa
   prpf8,  D.rerio
pre-mRNA processing factor 8
    NP_957270.2
2342 aa
   Prp8,  D.melanogaster
pre-mRNA processing factor 8
    NP_610735.1
2396 aa
   AgaP_AGAP006885,  A.gambiae
AgaP_AGAP006885
    XP_308873.2
2388 aa
   prp-8,  C.elegans
prp-8
    NP_498785.1
2329 aa
   PRP8,  S.cerevisiae
PRP8
    NP_012035.1
2413 aa
   KLLA0A05280g,  K.lactis
KLLA0A05280g
    XP_451233.1
2411 aa
   AGOS_ABR207W,  E.gossypii
AGOS_ABR207W
    NP_983156.2
2402 aa
   spp42,  S.pombe
spp42
    NP_593861.1
2363 aa
   MGG_05244,  M.oryzae
MGG_05244
    XP_003712798.1
2373 aa
   NCU07832,  N.crassa
NCU07832
    XP_962953.1
2374 aa
   SUS2,  A.thaliana
SUS2
    NP_178124.2
2359 aa
   AT4G38780,  A.thaliana
AT4G38780
    NP_195589.2
2332 aa
   Os06g0167000,  O.sativa
Os06g0167000
    NP_001056917.1
1099 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Retinitis pigmentosa-13.



Publications
Articles associated with genes and sequences of this homology group.

Structural elucidation of a PRP8 core domain from the heart of the spliceosome.
Ritchie DB, et al. Nat Struct Mol Biol 15, 1199-205 (2008).
Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.
Yang K, et al. Proc Natl Acad Sci U S A 105, 13817-22 (2008).
Prp8 protein: at the heart of the spliceosome.
Grainger RJ & Beggs JD. RNA 11, 533-57 (2005).
Proteomic analysis of interchromatin granule clusters.
Saitoh N, et al. Mol Biol Cell 15, 3876-90 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PROCN (pfam08083)
  PROCN (NUC071) domain.
U5_2-snRNA_bdg (pfam10597)
  U5-snRNA binding site 2 of PrP8.
PRO8NT (pfam08082)
  PRO8NT (NUC069), PrP8 N-terminal domain.
U6-snRNA_bdg (pfam10596)
  U6-snRNA interacting domain of PrP8.
PRP8_domainIV (pfam12134)
  PRP8 domain IV core.
RRM_4 (pfam10598)
  RNA recognition motif of the spliceosomal PrP8.
U6-snRNA_bdg (pfam10596)
  U6-snRNA interacting domain of PrP8.
MPN (cl13996)
  Mpr1p, Pad1p N-terminal (MPN) domains.
RNase_H_like (cl14782)
  Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prpf8 includes H.sapiens PRPF8 and R.norvegicus Prpf8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (26 transcripts, 10 species)
Mammalia - mammals (20 transcripts, 16 species)
Ascidiacea - tunicates (8 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (4 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (45 transcripts, 31 species)
Liliopsida - monocots (22 transcripts, 9 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (3 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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