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HomoloGene:446. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OTC,  H.sapiens
ornithine carbamoyltransferase
    NP_000522.3
354 aa
   OTC,  C.lupus
ornithine carbamoyltransferase
    XP_537995.1
354 aa
   OTC,  B.taurus
ornithine carbamoyltransferase
    NP_803453.1
354 aa
   Otc,  M.musculus
ornithine transcarbamylase
    NP_032795.1
354 aa
   Otc,  R.norvegicus
ornithine carbamoyltransferase
    NP_037210.1
354 aa
   OTC,  G.gallus
ornithine carbamoyltransferase
    NP_990241.1
354 aa
   otc,  X.tropicalis
ornithine carbamoyltransferase
    NP_001005795.1
351 aa
   otc,  D.rerio
ornithine carbamoyltransferase
    XP_001334671.1
352 aa
   ARG3,  S.cerevisiae
ARG3
    NP_012447.1
338 aa
   KLLA0F14366g,  K.lactis
KLLA0F14366g
    XP_455725.1
334 aa
   AGOS_AFR098W,  E.gossypii
AGOS_AFR098W
    NP_985645.1
349 aa
   arg3,  S.pombe
arg3
    NP_593692.1
327 aa
   MGG_01102,  M.oryzae
MGG_01102
    XP_003717832.1
351 aa
   NCU01667,  N.crassa
NCU01667
    XP_956873.2
359 aa
   OTC,  A.thaliana
OTC
    NP_177667.1
375 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ornithine transcarbamylase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Ornithine Transcarbamylase Deficiency
Lichter-Konecki U, et al. (1993).
Neurotransmitter receptor alterations in hepatic encephalopathy: a review.
Palomero-Gallagher N & Zilles K. Arch Biochem Biophys 536, 109-21 (2013).
Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese mice.
Murayama H, et al. J Gastroenterol Hepatol 25, 413-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OTCace (pfam00185)
  Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain.
OTCace_N (pfam02729)
  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.
OTCace (pfam00185)
  Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain.
OTCace_N (pfam02729)
  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Otc includes H.sapiens OTC and R.norvegicus Otc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (37 transcripts, 31 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (11 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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