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HomoloGene:37822. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   EEA1,  H.sapiens
early endosome antigen 1
1411 aa
   EEA1,  P.troglodytes
early endosome antigen 1
1411 aa
   EEA1,  M.mulatta
early endosome antigen 1
1411 aa
   EEA1,  C.lupus
early endosome antigen 1
1447 aa
   EEA1,  B.taurus
early endosome antigen 1
1452 aa
   Eea1,  M.musculus
early endosome antigen 1
1411 aa
   Eea1,  R.norvegicus
early endosome antigen 1
1411 aa
   EEA1,  G.gallus
early endosome antigen 1
1450 aa
   eea1,  X.tropicalis
early endosome antigen 1
1402 aa
   LOC562943,  D.rerio
novel protein similar to H.sapiens EEA1, early endosome antigen 1 (EEA1)
1398 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Investigation of the binding geometry of a peripheral membrane protein.
Brunecky R, et al. Biochemistry 44, 16064-71 (2005).
Association of early endosomal autoantigen 1 with macropinocytosis in EGF-stimulated A431 cells.
Hamasaki M, et al. Anat Rec A Discov Mol Cell Evol Biol 277, 298-306 (2004).
Multivalent endosome targeting by homodimeric EEA1.
Dumas JJ, et al. Mol Cell 8, 947-58 (2001).
Structural mechanism of endosome docking by the FYVE domain.
Kutateladze T & Overduin M. Science 291, 1793-6 (2001).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FYVE (pfam01363)
  FYVE zinc finger.
Smc (COG1196)
  Chromosome segregation ATPases [Cell division and chromosome partitioning].
Phage_GPO (cl15838)
  Phage capsid scaffolding protein (GPO) serine peptidase.
FYVE (cl17764)
  FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.
DUF342 (cl19219)
  Protein of unknown function (DUF342).
Trypsin_2 (cl19303)
  Trypsin-like peptidase domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eea1 includes H.sapiens EEA1 and R.norvegicus Eea1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Chromadorea - nematodes (3 transcripts, 2 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Arachnida - arachnids (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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