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HomoloGene:38258. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC19A2,  H.sapiens
solute carrier family 19 (thiamine transporter), member 2
    NP_008927.1
497 aa
   SLC19A2,  P.troglodytes
solute carrier family 19 (thiamine transporter), member 2
    XP_524958.2
497 aa
   SLC19A2,  M.mulatta
solute carrier family 19 (thiamine transporter), member 2
    XP_001093667.1
495 aa
   SLC19A2,  C.lupus
solute carrier family 19 (thiamine transporter), member 2
    XP_850843.2
499 aa
   SLC19A2,  B.taurus
solute carrier family 19 (thiamine transporter), member 2
    NP_001192939.1
496 aa
   Slc19a2,  M.musculus
solute carrier family 19 (thiamine transporter), member 2
    NP_473428.1
498 aa
   Slc19a2,  R.norvegicus
solute carrier family 19 (thiamine transporter), member 2
    NP_001025195.1
498 aa
   SLC19A2,  G.gallus
solute carrier family 19 (thiamine transporter), member 2
    XP_425529.2
483 aa
   LOC100489793,  X.tropicalis
thiamine transporter 1-like
    XP_002935829.1
489 aa
   slc19a2,  D.rerio
solute carrier family 19 (thiamine transporter), member 2
    XP_005168792.1
463 aa
   CG17036,  D.melanogaster
CG17036
    NP_609584.1
432 aa
   AgaP_AGAP006349,  A.gambiae
AgaP_AGAP006349
    XP_316371.4
479 aa
   folt-1,  C.elegans
folt-1
    NP_505833.3
453 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Thiamine-responsive megaloblastic anemia syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Reversible lactic acidosis in a newborn with thiamine transporter-2 deficiency.
Pérez-Dueñas B, et al. Pediatrics 131, e1670-5 (2013).
Thiamine-responsive megaloblastic anemia syndrome: a novel mutation.
Yilmaz Agladioglu S, et al. Genet Couns 23, 149-56 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MFS (cd06174)
  The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Folate_carrier (pfam01770)
  Reduced folate carrier.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc19a2 includes H.sapiens SLC19A2 and R.norvegicus Slc19a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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