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HomoloGene:4981. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   METAP2,  H.sapiens
methionyl aminopeptidase 2
    NP_006829.1
478 aa
   METAP2,  P.troglodytes
methionyl aminopeptidase 2
    XP_003313915.1
478 aa
   METAP2,  M.mulatta
methionyl aminopeptidase 2
    XP_001107008.1
478 aa
   METAP2,  C.lupus
methionyl aminopeptidase 2
    XP_005629295.1
477 aa
   METAP2,  B.taurus
methionyl aminopeptidase 2
    NP_001035583.1
477 aa
   Metap2,  M.musculus
methionine aminopeptidase 2
    NP_062622.1
478 aa
   Metap2,  R.norvegicus
methionyl aminopeptidase 2
    NP_071984.1
480 aa
   METAP2,  G.gallus
methionyl aminopeptidase 2
    NP_001006233.1
479 aa
   metap2,  X.tropicalis
methionyl aminopeptidase 2
    NP_001016115.1
483 aa
   metap2a,  D.rerio
methionyl aminopeptidase 2a
    NP_001093524.1
468 aa
   und,  D.melanogaster
uninitiated
    NP_477373.1
448 aa
   AgaP_AGAP008345,  A.gambiae
AgaP_AGAP008345
    XP_317113.3
505 aa
   MAP2,  S.cerevisiae
MAP2
    NP_009462.2
421 aa
   KLLA0E06887g,  K.lactis
KLLA0E06887g
    XP_454259.1
418 aa
   AGOS_AGL283W,  E.gossypii
AGOS_AGL283W
    NP_986384.2
349 aa
   fma2,  S.pombe
fma2
    NP_595906.1
426 aa
   MGG_00966,  M.oryzae
MGG_00966
    XP_003717984.1
443 aa
   NCU04306,  N.crassa
NCU04306
    XP_960952.1
481 aa
   MAP2A,  A.thaliana
MAP2A
    NP_566013.1
441 aa
   MAP2B,  A.thaliana
MAP2B
    NP_001190139.1
439 aa
   Os12g0628500,  O.sativa
Os12g0628500
    NP_001067330.1
450 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2.
Ng JY, et al. Biochem Biophys Res Commun 440, 37-42 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTZ00053 (PTZ00053)
  methionine aminopeptidase 2; Provisional.
APP_MetAP (cl00279)
  A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Metap2 includes H.sapiens METAP2 and R.norvegicus Metap2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (24 transcripts, 17 species)
Actinopterygii - bony fishes (17 transcripts, 8 species)
Ascidiacea - tunicates (6 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 12 species)
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (44 transcripts, 32 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (21 transcripts, 3 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (3 transcripts, 1 species)
Peronosporales - oomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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