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HomoloGene:55437. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FGFR3,  H.sapiens
fibroblast growth factor receptor 3
    NP_000133.1
806 aa
   FGFR3,  P.troglodytes
fibroblast growth factor receptor 3
    XP_003310269.1
808 aa
   FGFR3,  M.mulatta
fibroblast growth factor receptor 3
    XP_001101108.1
806 aa
   FGFR3,  C.lupus
fibroblast growth factor receptor 3
    XP_005618584.1
798 aa
   FGFR3,  B.taurus
fibroblast growth factor receptor 3
    NP_776743.1
802 aa
   Fgfr3,  M.musculus
fibroblast growth factor receptor 3
    NP_001156687.1
800 aa
   Fgfr3,  R.norvegicus
fibroblast growth factor receptor 3
    NP_445881.1
800 aa
   FGFR3,  G.gallus
fibroblast growth factor receptor 3
    NP_990840.2
827 aa
   fgfr3,  X.tropicalis
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
    NP_001135467.1
827 aa
   fgfr3,  D.rerio
fibroblast growth factor receptor 3
    NP_571681.1
800 aa
   htl,  D.melanogaster
heartless
    NP_732286.1
729 aa
   egl-15,  C.elegans
egl-15
    NP_001024723.1
988 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Achondroplasia.
Bladder cancer.
Colorectal cancer, somatic.
Crouzon syndrome with acanthosis nigricans.
Hypochondroplasia.
LADD syndrome.
Nevus, keratinocytic, nonepidermolytic.
Thanatophoric dysplasia, types I and II.
Muenke syndrome.
Cervical cancer, somatic.
CATSHL syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Synapse location during growth depends on glia location.
Shao Z, et al. Cell 154, 337-50 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IG_like (smart00410)
  Immunoglobulin like.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgfr3 includes H.sapiens FGFR3 and R.norvegicus Fgfr3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (4 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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