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HomoloGene:36304. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   CASP14,  H.sapiens
caspase 14, apoptosis-related cysteine peptidase
242 aa
   CASP14,  P.troglodytes
caspase 14, apoptosis-related cysteine peptidase
242 aa
   CASP14,  M.mulatta
caspase 14, apoptosis-related cysteine peptidase
242 aa
   CASP14,  C.lupus
caspase 14, apoptosis-related cysteine peptidase
248 aa
   CASP14,  B.taurus
caspase 14, apoptosis-related cysteine peptidase
242 aa
   Casp14,  M.musculus
caspase 14
257 aa
   Casp14,  R.norvegicus
caspase 14
246 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Ceramides stimulate caspase-14 expression in human keratinocytes.
Jiang YJ, et al. Exp Dermatol 22, 113-8 (2013).
Caspase-14-deficient mice are more prone to the development of parakeratosis.
Hoste E, et al. J Invest Dermatol 133, 742-50 (2013).
Function of caspase-14 in trophoblast differentiation.
White LJ, et al. Reprod Biol Endocrinol 7, 98 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CASc (cl00042)
  Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Casp14 includes H.sapiens CASP14 and R.norvegicus Casp14.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (3 transcripts, 3 species)




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