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HomoloGene:37368. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OPRM1,  H.sapiens
opioid receptor, mu 1
    NP_001272453.1
493 aa
   OPRM1,  P.troglodytes
opioid receptor, mu 1
    NP_001029087.1
401 aa
   OPRM1,  M.mulatta
opioid receptor, mu 1
    NP_001027996.1
400 aa
   OPRM1,  C.lupus
opioid receptor, mu 1
    XP_005615586.1
465 aa
   OPRM1,  B.taurus
opioid receptor, mu 1
    NP_776833.1
401 aa
   Oprm1,  M.musculus
opioid receptor, mu 1
    NP_001034741.1
438 aa
   Oprm1,  R.norvegicus
opioid receptor, mu 1
    NP_037203.1
398 aa
   OPRM1,  G.gallus
opioid receptor, mu 1
    XP_003641008.2
415 aa
   oprm1,  X.tropicalis
opioid receptor, mu 1
    XP_002933909.1
388 aa
   oprm1,  D.rerio
opioid receptor, mu 1
    NP_571782.1
384 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Response to morphine-6-glucuronide.
Epilepsy, idiopathic generalized, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.
Haerian BS & Haerian MS. Pharmacogenomics 14, 813-24 (2013).
Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses.
Wamsteeker Cusulin JI, et al. Nat Neurosci 16, 596-604 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Oprm1 includes H.sapiens OPRM1 and R.norvegicus Oprm1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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