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HomoloGene:7720. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FKBP8,  H.sapiens
FK506 binding protein 8, 38kDa
    NP_036313.3
413 aa
   FKBP8,  P.troglodytes
FK506 binding protein 8, 38kDa
    XP_512515.3
413 aa
   FKBP8,  M.mulatta
FK506 binding protein 8, 38kDa
    XP_001115431.2
413 aa
   FKBP8,  C.lupus
FK506 binding protein 8, 38kDa
    XP_541935.4
473 aa
   FKBP8,  B.taurus
FK506 binding protein 8, 38kDa
    NP_001192650.1
411 aa
   Fkbp8,  M.musculus
FK506 binding protein 8
    NP_001104536.1
403 aa
   Fkbp8,  R.norvegicus
FK506 binding protein 8
    NP_001032257.1
403 aa
   FKBP8,  G.gallus
FK506 binding protein 8, 38kDa
    NP_001241668.1
409 aa
   fkbp8,  X.tropicalis
FK506 binding protein 8, 38kDa
    NP_001120570.1
408 aa
   fkbp8,  D.rerio
FK506 binding protein 8
    NP_957178.1
406 aa
   CG5482,  D.melanogaster
CG5482
    NP_611353.1
397 aa
   AgaP_AGAP006615,  A.gambiae
AgaP_AGAP006615
    XP_316645.3
406 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Temporal expression pattern of Fkbp8 in rodent cochlea.
Zak M, et al. Cell Physiol Biochem 28, 1023-30 (2011).
New structural aspects of FKBP38 activation.
Maestre-Martínez M, et al. Biol Chem 391, 1157-67 (2010).
Solution structure of the FK506-binding domain of human FKBP38.
Maestre-Martínez M, et al. J Biomol NMR 34, 197-202 (2006).
The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.
Haupt K, et al. J Biol Chem 287, 19665-73 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FKBP_C (pfam00254)
  FKBP-type peptidyl-prolyl cis-trans isomerase.
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR_16 (pfam13432)
  Tetratricopeptide repeat.
FKBP_C (cl19519)
  FKBP-type peptidyl-prolyl cis-trans isomerase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fkbp8 includes H.sapiens FKBP8 and R.norvegicus Fkbp8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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