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Links from Protein

HomoloGene:3836. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ERCC4,  H.sapiens
excision repair cross-complementation group 4
NP_005227.1
916 aa
ERCC4,  P.troglodytes
excision repair cross-complementing rodent repair deficiency, complementation group 4
XP_510831.2
916 aa
ERCC4,  M.mulatta
excision repair cross-complementing rodent repair deficiency, complementation group 4
XP_001107209.1
916 aa
ERCC4,  C.lupus
excision repair cross-complementing rodent repair deficiency, complementation group 4
XP_536967.3
916 aa
ERCC4,  B.taurus
excision repair cross-complementing rodent repair deficiency, complementation group 4
NP_001192289.1
916 aa
Ercc4,  M.musculus
excision repair cross-complementing rodent repair deficiency, complementation group 4
NP_056584.2
917 aa
Ercc4,  R.norvegicus
excision repair cross-complementing rodent repair deficiency, complementation group 4
XP_006245762.1
910 aa
Ercc4l1,  R.norvegicus
excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1
XP_003750828.1
876 aa
ERCC4,  G.gallus
excision repair cross-complementing rodent repair deficiency, complementation group 4
XP_414734.3
903 aa
ercc4,  X.tropicalis
excision repair cross-complementing rodent repair deficiency, complementation group 4
XP_002935520.2
928 aa
ercc4,  D.rerio
excision repair cross-complementing rodent repair deficiency, complementation group 4
NP_956079.1
886 aa
mei-9,  D.melanogaster
meiotic 9
NP_525068.1
961 aa
AgaP_AGAP002805,  A.gambiae
AgaP_AGAP002805
XP_563334.4
1049 aa
RAD1,  S.cerevisiae
RAD1
NP_015303.1
1100 aa
KLLA0D12210g,  K.lactis
KLLA0D12210g
XP_453606.1
1056 aa
AGOS_AFR456C,  E.gossypii
AGOS_AFR456C
NP_986003.1
1015 aa
rad16,  S.pombe
rad16
NP_587855.2
877 aa
MGG_02804,  M.oryzae
MGG_02804
XP_003720937.1
960 aa
NCU07440,  N.crassa
NCU07440
XP_964627.2
957 aa
UVH1,  A.thaliana
UVH1
NP_198931.1
956 aa
Os03g0100400,  O.sativa
Os03g0100400
NP_001048645.1
995 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
mei-9 alleles confer sensitivity to mutagens as a consequence of a defect in excision repair (Boyd et al., 1976; Nguyen and Boyd, 1977). This defect in DNA repair is also manifested by a high frequency of mitotic chromosome breakage and instability (Baker et al., 1978; Gatti, 1979). For example, larval neuroblasts of mei-9/Y males display a high frequency of spontaneous chromosome breaks in both the eu- and heterochromatin (Gatti, 1979). Females homozygous for mei-9 show greatly reduced levels of meiotic exchange. (See FlyBase for complete description.)

H.sapiens
Xeroderma pigmentosum, group F.
XFE progeroid syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Xeroderma pigmentosum complementation group f polymorphisms influence risk of glioma.
Cheng HB, et al. Asian Pac J Cancer Prev 14, 4083-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
rad1 (TIGR00596)
  DNA repair protein (rad1).
ERCC4 (cl10594)
  This domain is a family of nucleases. The family includes EME1 which is an essential component of a Holliday junction resolvase. EME1 interacts with MUS81 to form a DNA structure-specific endonuclease.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ercc4 includes H.sapiens ERCC4 and R.norvegicus Ercc4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 7 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (11 transcripts, 10 species)
Liliopsida - monocots (9 transcripts, 8 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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