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HomoloGene:3489. Gene conserved in Euteleostomi Download ,
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   CRLF1,  H.sapiens
cytokine receptor-like factor 1
422 aa
   CRLF1,  P.troglodytes
cytokine receptor-like factor 1
709 aa
   CRLF1,  M.mulatta
cytokine receptor-like factor 1
470 aa
   CRLF1,  C.lupus
cytokine receptor-like factor 1
564 aa
   CRLF1,  B.taurus
cytokine receptor-like factor 1
424 aa
   Crlf1,  M.musculus
cytokine receptor-like factor 1
425 aa
   Crlf1,  R.norvegicus
cytokine receptor-like factor 1
425 aa
   CRLF1,  G.gallus
cytokine receptor-like factor 1
516 aa
   crlf1,  X.tropicalis
cytokine receptor-like factor 1
387 aa
   crlf1a,  D.rerio
cytokine receptor-like factor 1a
389 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Cold-induced sweating syndrome.
Crisponi syndrome.

Articles associated with genes and sequences of this homology group.

Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
Alexander WS, et al. Curr Biol 9, 605-8 (1999).
Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene.
Knappskog PM, et al. Am J Hum Genet 72, 375-83 (2003).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Lep_receptor_Ig (pfam06328)
  Ig-like C2-type domain.
IL6Ra-bind (cl12153)
  Interleukin-6 receptor alpha chain, binding.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
Vert_HS_TF (pfam06546)
  Vertebrate heat shock transcription factor.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Crlf1 includes H.sapiens CRLF1 and R.norvegicus Crlf1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 6 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)




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