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HomoloGene:73874. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COL1A1,  H.sapiens
collagen, type I, alpha 1
    NP_000079.2
1464 aa
   COL1A1,  P.troglodytes
collagen, type I, alpha 1
    XP_001169409.1
1464 aa
   COL1A1,  M.mulatta
collagen, type I, alpha 1
    XP_001096194.2
1432 aa
   COL1A1,  C.lupus
collagen, type I, alpha 1
    NP_001003090.1
1460 aa
   COL1A1,  B.taurus
collagen, type I, alpha 1
    NP_001029211.1
1463 aa
   Col1a1,  M.musculus
collagen, type I, alpha 1
    NP_031768.2
1453 aa
   Col1a1,  R.norvegicus
collagen, type I, alpha 1
    NP_445756.1
1453 aa
   LOC496414,  X.tropicalis
uncharacterized LOC496414
    NP_001011005.1
1449 aa
   col1a1a,  D.rerio
collagen, type I, alpha 1a
    NP_954684.1
1447 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Caffey disease.
Dissection of cervical arteries.
OI/EDS combined syndrome.
Ehlers-Danlos syndrome, type I.
Ehlers-Danlos syndrome, type VII.
Osteogenesis imperfecta, type I.
OI type II.
OI type IV.
Osteoporosis.
OI type III.



Publications
Articles associated with genes and sequences of this homology group.

Ex-vivo assessment and non-invasive in vivo imaging of internal hemorrhages in Aga2/+ mutant mice.
Ermolayev V, et al. Biochem Biophys Res Commun 432, 389-93 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COLFI (pfam01410)
  Fibrillar collagen C-terminal domain.
VWC (pfam00093)
  von Willebrand factor type C domain.
COLFI (cl02436)
  Fibrillar collagen C-terminal domain.
VWC (cl17735)
  von Willebrand factor type C domain.
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col1a1 includes H.sapiens COL1A1 and R.norvegicus Col1a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (24 transcripts, 13 species)
Actinopterygii - bony fishes (23 transcripts, 12 species)
Aves - birds (4 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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