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HomoloGene:7751. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HLA-DRA,  H.sapiens
major histocompatibility complex, class II, DR alpha
    NP_061984.2
254 aa
   PATR-DRA,  P.troglodytes
major histocompatibility complex, class II, DR alpha
    NP_001127811.1
254 aa
   MAMU-DRA,  M.mulatta
major histocompatibility complex, class II, DR alpha
    NP_001127770.1
254 aa
   DLA-DRA,  C.lupus
MHC class II DR alpha chain
    NP_001011723.1
254 aa
   BOLA-DRA,  B.taurus
major histocompatibility complex, class II, DR alpha
    NP_001012695.1
253 aa
   H2-Ea-ps,  M.musculus
histocompatibility 2, class II antigen E alpha, pseudogene
    XP_003688998.1
276 aa
   RT1-Da,  R.norvegicus
RT1 class II, locus Da
    NP_001008847.1
255 aa
   BLA,  G.gallus
Major histocompatibility complex class II alpha chain BLA, (similar to HLA class II, D alpha chain)
    NP_001231990.1
255 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The HLA-DRA variation rs3129882 is not associated with Parkinson's disease in Sweden.
Ran C, et al. Parkinsonism Relat Disord 19, 701-2 (2013).
Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease.
Chiang HL, et al. Parkinsonism Relat Disord 18, 391-3 (2012).
Human leukocyte antigen variation and Parkinson's disease.
Puschmann A, et al. Parkinsonism Relat Disord 17, 376-8 (2011).
Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions.
Taflin C, et al. Proc Natl Acad Sci U S A 108, 2891-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MHC_II_alpha (cl03058)
  Class II MHC glycoproteins are expressed on the surface of antigen-presenting cells (APC), including macrophages, dendritic cells and B cells. MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and inflammatory T cells (cause the release of lymphokines that attract other cells to site of infection).
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus H2-Ea-ps includes H.sapiens HLA-DRA.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 16 species)

 

 

 

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