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HomoloGene:38189. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   POLH,  H.sapiens
polymerase (DNA directed), eta
    NP_006493.1
713 aa
   POLH,  P.troglodytes
polymerase (DNA directed), eta
    XP_518497.1
713 aa
   POLH,  M.mulatta
polymerase (DNA directed), eta
    XP_002803805.1
730 aa
   POLH,  C.lupus
polymerase (DNA directed), eta
    XP_532150.2
712 aa
   POLH,  B.taurus
polymerase (DNA directed), eta
    NP_001029622.1
711 aa
   Polh,  M.musculus
polymerase (DNA directed), eta (RAD 30 related)
    NP_109640.1
694 aa
   Polh,  R.norvegicus
polymerase (DNA directed), eta
    NP_001101674.1
689 aa
   POLH,  G.gallus
polymerase (DNA directed), eta
    NP_001001304.1
673 aa
   polh,  X.tropicalis
polymerase (DNA directed), eta
    XP_002942198.2
253 aa
   polh,  D.rerio
polymerase (DNA directed), eta
    NP_001035337.1
743 aa
   polh-1,  C.elegans
polh-1
    NP_497480.2
584 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Xeroderma pigmentosum, variant type.



Publications
Articles associated with genes and sequences of this homology group.

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.
Zhao Y, et al. Proc Natl Acad Sci U S A 110, 8146-51 (2013).
Biochemical analysis of active site mutations of human polymerase η.
Suarez SC, et al. Mutat Res 745-746, 46-54 (2013).
Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.
Zhao Y, et al. Proc Natl Acad Sci U S A 109, 7269-74 (2012).
Structure and mechanism of human DNA polymerase eta.
Biertümpfel C, et al. Nature 465, 1044-8 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PolY (cl12025)
  Y-family of DNA polymerases.
PolY (cl12025)
  Y-family of DNA polymerases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Polh includes H.sapiens POLH and R.norvegicus Polh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (5 transcripts, 5 species)
Liliopsida - monocots (5 transcripts, 5 species)

 

 

 

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