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HomoloGene:32370. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SDHAF2,  H.sapiens
succinate dehydrogenase complex assembly factor 2
    NP_060311.1
166 aa
   PPP1R32,  P.troglodytes
protein phosphatase 1, regulatory subunit 32
    NP_001238783.1
166 aa
   SDHAF2,  M.mulatta
succinate dehydrogenase complex assembly factor 2
    XP_001082359.2
166 aa
   SDHAF2,  C.lupus
succinate dehydrogenase complex assembly factor 2
    XP_533273.2
165 aa
   SDHAF2,  B.taurus
succinate dehydrogenase complex assembly factor 2
    NP_001070513.1
166 aa
   Sdhaf2,  M.musculus
succinate dehydrogenase complex assembly factor 2
    NP_079609.2
164 aa
   Sdhaf2,  R.norvegicus
succinate dehydrogenase complex assembly factor 2
    NP_001008372.1
164 aa
   LOC426015,  G.gallus
succinate dehydrogenase assembly factor 2, mitochondrial-like
    NP_001264818.1
159 aa
   sdhaf2,  X.tropicalis
succinate dehydrogenase complex assembly factor 2
    XP_002937676.1
153 aa
   sdhaf2,  D.rerio
succinate dehydrogenase complex assembly factor 2
    NP_001076333.1
158 aa
   CG14757,  D.melanogaster
CG14757
    NP_610363.1
163 aa
   CG12895,  D.melanogaster
CG12895
    NP_001260868.1
156 aa
   AgaP_AGAP012191,  A.gambiae
AgaP_AGAP012191
    XP_320341.4
145 aa
   EMI5,  S.cerevisiae
EMI5
    NP_014570.1
162 aa
   KLLA0E13333g,  K.lactis
KLLA0E13333g
    XP_454550.1
163 aa
   AGOS_AER200C,  E.gossypii
AGOS_AER200C
    NP_985057.1
160 aa
   MGG_07034,  M.oryzae
MGG_07034
    XP_003715216.1
236 aa
   NCU01343,  N.crassa
NCU01343
    XP_961429.1
221 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Paragangliomas 2.



Publications
Articles associated with genes and sequences of this homology group.

SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma.
Kunst HP, et al. Clin Cancer Res 17, 247-54 (2011).
Emerging concepts in the flavinylation of succinate dehydrogenase.
Kim HJ & Winge DR. Biochim Biophys Acta 1827, 627-36 (2013).
The role of complex II in disease.
Hoekstra AS & Bayley JP. Biochim Biophys Acta 1827, 543-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sdh5 (pfam03937)
  Flavinator of succinate dehydrogenase.
Sdh5 (cl01110)
  Flavinator of succinate dehydrogenase.
Sdh5 (cl01110)
  This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans. Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterized as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria. This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sdhaf2 includes H.sapiens SDHAF2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 10 species)
Aves - birds (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (13 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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