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HomoloGene:74294. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HSPA1A,  H.sapiens
heat shock 70kDa protein 1A
    NP_005336.3
641 aa
   HSPA1B,  H.sapiens
heat shock 70kDa protein 1B
    NP_005337.2
641 aa
   HSPA1A,  P.troglodytes
heat shock 70kDa protein 1A
    XP_003311223.1
641 aa
   HSPA1B,  M.mulatta
heat shock 70kDa protein 1B
    XP_001115060.2
555 aa
   LOC102155697,  C.lupus
heat shock 70 kDa protein 1-like
    XP_005627221.1
641 aa
   HSPA1A,  B.taurus
heat shock 70kDa protein 1A
    NP_976067.2
641 aa
   Hspa1a,  M.musculus
heat shock protein 1A
    NP_034609.2
641 aa
   Hspa1a,  R.norvegicus
heat shock 70kD protein 1A
    NP_114177.2
641 aa
   Hspa1b,  R.norvegicus
heat shock 70kD protein 1B (mapped)
    NP_997669.1
641 aa
   hspa1l,  X.tropicalis
heat shock 70kDa protein 1-like
    NP_001072429.1
639 aa
   LOC100485441,  X.tropicalis
heat shock 70 kDa protein-like
    XP_002937685.1
639 aa
   hsp70,  X.tropicalis
heat shock 70kDa protein
    NP_001106370.1
643 aa
   hsc70,  D.rerio
heat shock cognate 70
    NP_956908.1
647 aa
   Hsp70Ba,  D.melanogaster
Heat-shock-protein-70Ba
    NP_731716.1
641 aa
   Hsc70-2,  D.melanogaster
Heat shock protein cognate 2
    NP_524339.1
633 aa
   Hsp68,  D.melanogaster
Heat shock protein 68
    NP_524474.1
635 aa
   Hsp70Bc,  D.melanogaster
Heat-shock-protein-70Bc
    NP_650209.1
641 aa
   Hsp70Aa,  D.melanogaster
Heat-shock-protein-70Aa
    NP_731651.1
642 aa
   Hsp70Ab,  D.melanogaster
Heat-shock-protein-70Ab
    NP_524798.2
642 aa
   Hsp70Bb,  D.melanogaster
Heat-shock-protein-70Bb
    NP_524927.2
641 aa
   Hsp70Bbb,  D.melanogaster
Hsp70Bbb
    NP_788663.1
641 aa
   SSA4,  S.cerevisiae
SSA4
    NP_011029.3
642 aa
   SSA3,  S.cerevisiae
SSA3
    NP_009478.1
649 aa
   KLLA0E20527g,  K.lactis
KLLA0E20527g
    XP_454878.1
650 aa
   AGOS_AER187W,  E.gossypii
AGOS_AER187W
    NP_985044.2
649 aa
   AT5G02490,  A.thaliana
AT5G02490
    NP_195869.1
653 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
One of five structural genes (in two clusters, Hsp70A and Hsp70B) that code for the 70,000 dalton heat-shock protein (HSP70), the most abundant of the heat-shock proteins. Hsp70B usually includes three HSP70 encoding genes (Hsp70Ba (proximal), Hsp70Bb (middle), Hsp70Bc (distal)) (Holmgren, Livak, Morimoto, Freund, and Meselson, 1979) with slightly different restriction maps (Artavanis-Tsakonas et al., 1978). HSP70 returns to preshock levels more rapidly than other heat-shock proteins following return to 25oC (DiDomenico, Bugaisky and Lindquist, 1982). (See FlyBase for complete description.)
First recognized by sequence similarity to Hsp70. Transcription is developmentally regulated, but is temperature independent.
The structural gene for the 68,000 dalton heat-shock protein (HSP68)
One of five structural genes (in two clusters, Hsp70A and Hsp70B) that code for the 70,000 dalton heat-shock protein (HSP70), the most abundant of the heat-shock proteins. Hsp70B usually includes three HSP70 encoding genes (Hsp70Ba (proximal), Hsp70Bb (middle), Hsp70Bc (distal)) (Holmgren et al., 1979) with slightly different restriction maps (Artavanis-Tsakonas, Steward, Gehring, Mirault, Goldschmidt-Clermont, Moran and Tissieres, 1978). HSP70 returns to preshock levels more rapidly than other heat-shock proteins following return to 25oC (DiDomenico, Bugaisky and Lindquist, 1982). (See FlyBase for complete description.)
One of five structural genes (in two clusters, Hsp70A and Hsp70B) that code for the 70,000 dalton heat-shock protein (HSP70), the most abundant of the heat-shock proteins. Hsp70A usually includes two HSP70 encoding genes (Hsp70Aa (proximal), Hsp70Ab (distal)) (Holmgren et al., 1979) with slightly different restriction maps (Artavanis-Tsakonas et al., 1978). HSP70 returns to preshock levels more rapidly than other heat-shock proteins following return to 25oC (DiDomenico, Bugaisky and Lindquist, 1982). (See FlyBase for complete description.)
One of five structural genes (in two clusters, Hsp70A and Hsp70B) that code for the 70,000 dalton heat-shock protein (HSP70), the most abundant of the heat-shock proteins. Hsp70A usually includes two HSP70 encoding genes (Hsp70Aa (proximal), Hsp70Ab (distal)) (Holmgren, Livak, Morimoto, Freund, and Meselson, 1979) with slightly different restriction maps (Artavanis-Tsakonas, Steward, Gehring, Mirault, Goldschmidt-Clermont, Moran and Tissieres, 1978). HSP70 returns to preshock levels more rapidly than other heat-shock proteins following return to 25oC (DiDomenico et al., 1982). (See FlyBase for complete description.)
One of five structural genes (in two clusters, Hsp70A, Hsp70B) that code for the 70,000 dalton heat-shock protein (HSP70), the most abundant of the heat-shock proteins. Hsp70B usually includes three HSP70 encoding genes (Hsp70Ba (proximal), Hsp70Bb (middle), Hsp70Bc (distal)) (Holmgren et al., 1979) with slightly different restriction maps (Artavanis-Tsakonas et al., 1978). HSP70 returns to preshock levels more rapidly than other heat-shock proteins following return to 25oC (DiDomenico, Bugaisky and Lindquist, 1982). (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Inner ear supporting cells protect hair cells by secreting HSP70.
May LA, et al. J Clin Invest 123, 3577-87 (2013).
The antioxidative effect of heat-shock protein 70 in dendritic cells.
Je JH, et al. Scand J Immunol 78, 238-47 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTZ00009 (PTZ00009)
  heat shock 70 kDa protein; Provisional.
NBD_sugar-kinase_HSP70_actin (cl17037)
  Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hspa1a includes H.sapiens HSPA1A and R.norvegicus Hspa1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (24 transcripts, 15 species)
Actinopterygii - bony fishes (18 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (34 transcripts, 11 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (16 transcripts, 10 species)
Liliopsida - monocots (4 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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