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HomoloGene:8534. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHMP2B,  H.sapiens
charged multivesicular body protein 2B
    NP_054762.2
213 aa
   CHMP2B,  P.troglodytes
charged multivesicular body protein 2B
    XP_003950194.1
213 aa
   CHMP2B,  M.mulatta
charged multivesicular body protein 2B
    XP_001104518.1
213 aa
   CHMP2B,  C.lupus
charged multivesicular body protein 2B
    XP_544799.3
213 aa
   CHMP2B,  B.taurus
charged multivesicular body protein 2B
    NP_001030549.1
213 aa
   Chmp2b,  M.musculus
charged multivesicular body protein 2B
    NP_081155.1
213 aa
   Chmp2b,  R.norvegicus
charged multivesicular body protein 2B
    XP_343996.5
213 aa
   CHMP2B,  G.gallus
charged multivesicular body protein 2B
    NP_001025963.1
214 aa
   chmp2b,  X.tropicalis
charged multivesicular body protein 2B
    NP_998866.1
214 aa
   chmp2bb,  D.rerio
chromatin modifying protein 2Bb
    NP_998069.1
214 aa
   CHMP2B,  D.melanogaster
Charged multivesicular body protein 2b
    NP_647947.1
212 aa
   C01A2.4,  C.elegans
C01A2.4
    NP_493357.2
207 aa
   VPS2.3,  A.thaliana
VPS2.3
    NP_563696.1
210 aa
   Os10g0476400,  O.sativa
Os10g0476400
    NP_001064848.1
212 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dementia, familial, nonspecific.
Amyotrophic lateral sclerosis, CHMP2B-related.



Publications
Articles associated with genes and sequences of this homology group.

Localization of CHMP2B-immunoreactivity in the brainstem of Lewy body disease.
Kurashige T, et al. Neuropathology 33, 237-45 (2013).
Frontotemporal dementia caused by CHMP2B mutations.
Isaacs AM, et al. Curr Alzheimer Res 8, 246-51 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chmp2b includes H.sapiens CHMP2B and R.norvegicus Chmp2b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (13 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (33 transcripts, 30 species)
Liliopsida - monocots (8 transcripts, 8 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

 

 

 

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