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HomoloGene:474. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   IL6R,  H.sapiens
interleukin 6 receptor
468 aa
   IL6R,  P.troglodytes
interleukin 6 receptor
468 aa
   IL6R,  M.mulatta
interleukin 6 receptor
468 aa
   IL6R,  C.lupus
interleukin 6 receptor
468 aa
   IL6R,  B.taurus
interleukin 6 receptor
464 aa
   Il6ra,  M.musculus
interleukin 6 receptor, alpha
460 aa
   Il6r,  R.norvegicus
interleukin 6 receptor
462 aa
   il6r,  X.tropicalis
interleukin 6 receptor
234 aa
   il6r,  D.rerio
interleukin 6 receptor
580 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo J, et al. J Allergy Clin Immunol 132, 371-7 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IG_like (smart00410)
  Immunoglobulin like.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il6ra includes H.sapiens IL6R and R.norvegicus Il6ra.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)




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