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HomoloGene:4380. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   WFS1,  H.sapiens
Wolfram syndrome 1 (wolframin)
890 aa
   WFS1,  P.troglodytes
Wolfram syndrome 1 (wolframin)
846 aa
   WFS1,  M.mulatta
Wolfram syndrome 1 (wolframin)
890 aa
   WFS1,  C.lupus
Wolfram syndrome 1 (wolframin)
888 aa
   WFS1,  B.taurus
Wolfram syndrome 1 (wolframin)
888 aa
   Wfs1,  M.musculus
Wolfram syndrome 1 homolog (human)
890 aa
   Wfs1,  R.norvegicus
Wolfram syndrome 1 (wolframin)
890 aa
   WFS1,  G.gallus
Wolfram syndrome 1 (wolframin)
874 aa
   wfs1,  X.tropicalis
Wolfram syndrome 1 (wolframin)
863 aa
   wfs1b,  D.rerio
Wolfram syndrome 1b (wolframin)
895 aa
   wfs1,  D.melanogaster
wolfram syndrome 1
852 aa
   AgaP_AGAP004409,  A.gambiae
915 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Wolfram syndrome.
Wolfram-like syndrome, autosomal dominant.
Hearing loss, low-frequency sensorineural.

Articles associated with genes and sequences of this homology group.

Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation.
Bonnycastle LL, et al. Diabetes 62, 3943-50 (2013).
Association of aggression with a novel microRNA binding site polymorphism in the wolframin gene.
Kovacs-Nagy R, et al. Am J Med Genet B Neuropsychiatr Genet 162B, 404-12 (2013).
Evidence for impaired function of dopaminergic system in Wfs1-deficient mice.
Visnapuu T, et al. Behav Brain Res 244, 90-9 (2013).
Circadian rhythms and food anticipatory behavior in Wfs1-deficient mice.
Luuk H, et al. Biochem Biophys Res Commun 424, 717-23 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COG0790 (COG0790)
  FOG: TPR repeat, SEL1 subfamily [General function prediction only].
mviN (TIGR01695)
  integral membrane protein MviN.
SMC_prok_A (TIGR02169)
  chromosome segregation protein SMC, primarily archaeal type.
RNA_polI_A34 (pfam08208)
  DNA-directed RNA polymerase I subunit RPA34.5.
Sel1 (cl02723)
  This short repeat is found in the Sel1 protein. It is related to TPR repeats.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Wfs1 includes H.sapiens WFS1 and R.norvegicus Wfs1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)




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